Objectives To assess the long-term clinical outcomes in patients with coronary artery disease and diabetes mellitus after biodegradable polymer sirolimus-eluting stent based percutaneous coronary intervention.
Methods The patients with coronary artery disease were treated with PCI for target lesions, Including 162 diabetic patients 45 to 83 years old and 150 non-diabetic patients aged 43-86 years old in our centre from January to December 2007. Drug-eluting stents were successfully implanted on target lesions. The five years follow-up recurrent angina, clinical end points of death, myocardial infarction, stroke and any repeat revascularisation were made through case record review and mainly by telephone interview after discharge retrospectively.
Results The procedural success rate was 100% for both goups 100% of the cohort was followed successfully. The median time of follow-up was 5 years. At 5 years follow-up. There were no significant differences in complication rate (8.8% vs 7.0%), non-fatal stroke (3.92% vs 3.0%) and non-fatal heart disease (0% vs 0%) (all p > 0.05). Recurrent angina (42,1% vs 30.0%) and repeat revascularisation rate (30.4% vs 14.0%) and mortality (9.8% vs 2.0%) were higher in diabetic group than in non-diabetic group respectively (all ρ < 0.05). cardiac death was 0%.
Conclusions Implanting sirolimus-eluting stents in patients with coronary artery disease and diabetes mellitus during PCI is safe and effective. Diabetic patients undergoing elective coronary stenting have acceptable long-term outcomes, but diabetes mellitus is still independently associated with worse late prognosis.
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