Objectives To investigate the association between Serum Uric Acid (SUA) and endothelial function in Chinese hypertentive patients with or without Metabolic Syndrome (MS).
Methods SUA and endothelial function were evaluated in 615 hypertensive patients and 87 age- and sex-matched healthy controls. All subjects were classified into three groups: hypertensive patients with MS (MS group), hypertensive patients without MS (NMS group) and healthy control group (NC group). SUA was detected by the uricase peroxidase method. Endothelium-dependent dilatation (EDD based on the brachial flow mediated dilatation, FMD) and endothelium-independent vasodilation (EID) was determined using high-resolution vascular ultrasound.
Results Increased SUA concentrations were found gradually among NC group, NMS group and MS group (323.77 ± 104.49 vs 353.63 ± 92.83 vs 390.90 ± 101.42 umol/l, p < 0.01). Correspondingly, the prevalence of hyperuricemia was shown among the groups (4/87 (4.6%) vs 120/376 (31.9%) vs 120/239 (50.2%), p < 0.01). Nevertheless, values of FMD showed the inverse trend (12.03 ± 4.51% vs 8.98 ± 4.32% vs 8.23 ± 4.58%, p < 0.01). After stratification, It was showed that only male hyperuricemic patients younger than 60 years in MS group appeared to have significantly lower FMD than those without hyperuricemia (7.12 ± 4.49% vs 9.98 ± 5.78%, P < 0.05); Significant correlations between SUA and FMD were also found (r = -0.314, p < 0.01); Finally, logistic regression analysis further showed that a 50 umol/L increase in the concentration of SUA signalled a 45.0% higher risk for endothelial dysfunction in this cohort.
Conclusions Hypertensive patients with MS have worse endothelial function. In male aged less than 60 years old, SUA levels are inversely associated with endothelial function.
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