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GW24-e2915 Gender may affect the risk and effect of atrial fibrillation in patient with apical hypertrophic cardiomyopathy
  1. Yang Yinjian1,
  2. Yan Lirong1,
  3. Li Yishi1,
  4. Huang Yiling1,
  5. Liu Hong1,
  6. Liu Yuqing1,
  7. Tian Lei1,
  8. Wang Zhimin2,
  9. Duan Fujian2,
  10. Fan Chaomei1
  1. 1Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, Fuwai Hospital, CAMS & PUMC
  2. 2Division of Ultrasound, Fuwai Hospital, CAMS & PUMC


Objectives Analysing and summarising the clinical and echocardiographic characteristics of middle-aged and young apical hypertrophic cardiomyopathy patients (ApHCM).

Methods Patients with ApHCM who were diagnosed by echocardiography or magnetic resonance imaging between Januray 1994 and Januray 2009 at Fuwai hospital and less than 65 years old were consecutively enrolled in this study.

Results A total of 169 patients with ApHCM were enrolled, including 131 males and 38 females. The frequency of palpitation (29/131 vs. 15/38, P = 0.032) and atrial fibrillation (7/131 vs. 8/38, P = 0.007) is higher in female patients. There is no significant difference in left ventricular ejection fraction (LVEF) (59.3% ± 11.4% vs. 64.6% ± 7.7%, P = 0.131) between female patients with and without atrial fibrillation. However, for the male group, LVEF is lower in patients with atrial fibrillation (57.0% ± 11.5% vs 67.6% ± 9.2%, P = 0.010).

Conclusions Female patients are more prone to atrial fibrillation and palpitation than male patients. Though atrial fibrillation may significantly reduce the LVEF of male patients, this effect is not obvious in the female group, indicating the effect of atrial fibrillation on LVEF may be affected by the gender.

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