Article Text

PDF
Original research article
Selection bias, interventions and outcomes for survivors of cardiac arrest
  1. David J Wallace1,2,3,
  2. Patrick Coppler2,
  3. Clifton Callaway3,
  4. Jon C Rittenberger3,
  5. Cameron Dezfulian1,2,
  6. Deepika Mohan1,2,4,
  7. Catalin Toma5,
  8. Jonathan Elmer2,3
  1. 1Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  2. 2Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  3. 3Department of Emergency Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  4. 4Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  5. 5Division of Cardiology, Department of Internal Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  1. Correspondence to Dr David J Wallace, Department Critical Care, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA; wallaced{at}pitt.edu

Abstract

Objective Cardiac catheterisation and implantable cardioverter defibrillator (ICD) insertion are increasingly common following cardiac arrest survival. However, much of the evidence for the benefit is observational, leaving open the possibility that biased patient selection confounds the association between these invasive procedures and improved outcome. We evaluated the likelihood of selection bias in the association between cardiac catheterisation or ICD placement and outcome by measuring long-term outcomes overall and in a cause-specific approach that separated cardiac mortality from non-cardiac mortality.

Methods We performed a multivariable survival analysis of a clinical cohort between 2005 and 2013, with follow-up through 2015. We included patients who had out-of-hospital or inhospital cardiac arrest that survived to discharge, and evaluated the association between cardiac catheterisation or ICD insertion and all-cause, cardiovascular and non-cardiovascular mortality.

Results Among 678 patients who survived cardiac arrest, we observed lower all-cause mortality among patients who underwent cardiac catheterisation (adjusted HR (aHR) 0.40; P<0.01) or ICD insertion (aHR 0.55; P<0.01). However, cause-specific analysis showed that the benefits of cardiac catheterisation and ICD insertion resulted from reduced non-cardiac causes of death (cardiac catheterisation: aHR 0.24, P<0.01; ICD: aHR 0.58, P<0.01), while reduced cardiac cause of death was not associated with cardiac catheterisation (cardiac catheterisation: aHR 0.75, P=0.33).

Conclusions There is evidence of selection bias in the secondary prevention survival benefit attributable to cardiac catheterisation for patients who survive cardiac arrest. Observational studies that consider its effects on all-cause mortality likely overestimate the potential benefit of this procedure.

  • cardiac arrest
  • cardiac catheterization and angiography
  • epidemiology
  • quality and outcomes of care

Statistics from Altmetric.com

Footnotes

  • Contributors DJW, PC, CC and JE conceptualised and designed the study. DJW, PC and JE carried out the analysis. DJW, PC, CC, JCR, CD, DM, CT and JE interpreted the findings. DJW drafted the initial manuscript. PC, CC, JCR, CD, DM, CT and JE critically reviewed the draft manuscript and made substantial contributions. All authors approved the final manuscript as submitted.

  • Funding All phases of this study were supported by NIH grants K08HL122478 (DJW), K12HL109068 (JE) and DP2 LM012339 (DM).

  • Competing interests None declared.

  • Ethics approval The University of Pittsburgh Institutional Review Board approved all aspects of the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Per the data use agreement with the University of Pittsburgh, the data used in this research are not available for sharing or distribution.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.