Objective The role of age in clinical characteristics and catheter ablation outcomes of atrioventricular nodal re-entrant tachycardia (AVNRT) or orthodromic atrioventricular re-entrant tachycardia (AVRT) has been assessed in retrospective studies categorising age by arbitrary cut-offs, but contemporary analyses of age-related trends are lacking. We aimed to study the relationship of age with epidemiological, clinical features and catheter ablation outcomes of AVNRT and AVRT.
Methods We recruited 600 patients (median age 56 years, 60% female) with a confirmed diagnosis of AVNRT (n=455) or AVRT (n=145) by means of an electrophysiological study. They were interrogated for arrhythmia-related symptoms with a structured questionnaire and followed up to 1 year. We analysed age as a continuous variable using regression models and adjusting for relevant covariables.
Results Both typical and atypical forms of AVNRT upraised with age while AVRT decreased (p<0.001 by regression). Female sex predominance in AVNRT was not observed in older patients. Overall, these tachycardias became more symptomatic with ageing despite a longer tachycardia cycle length (p<0.001) and regardless of the presence of structural heart disease, with a higher proportion of dizziness, syncope, chest pain or dyspnoea (p<0.005 for all) and a lower presence of palpitations or neck pounding (p<0.001 for both). Age was not associated with catheter ablation acute success, periprocedural complications or 1-year recurrence rates (p>0.05 for all).
Conclusions Age, evaluated as a continuous variable, had a significant association with the clinical profile of patients with AVNRT and AVRT. Nevertheless, catheter ablation outcomes and complications were not significantly related to patients’ age.
- catheter ablation
Data availability statement
Data are available upon reasonable request.
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Contributors PA and EG-T designed the study. PA, DC, MT, AU and EG-T identified the patients and collected the data. PA, DC and EG-T conducted the data analysis and drafted the manuscript. All authors provided substantial contribution to the interpretation of the results and revision of the manuscript for important intellectual content. All authors provided final approval of the version to be published in agreement with ensuring the integrity and accuracy of the work. The corresponding author (PA) attests that all the listed authors meet the authorship criteria.
Funding MT is funded by a Rio Hortega contract (CM20/00054). NS is funded by the Spanish Heart Rhythm Association for training in cardiac electrophysiology.
Competing interests PA received teaching honoraria from Medtronic and served as Advisory Board member for Boston Scientific. FA served as Advisory Board member for Medtronic and MicroPort. TD received teaching honoraria from Medtronic. AA is a consultant for Medtronic and Boston Scientific. The remaining authors do not have disclosures to declare.
Provenance and peer review Not commissioned; externally peer reviewed.
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