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The Authors’ reply We thank Dr Madias for his interest in our study and for the opportunity to further discuss the long-term effects of beta-blockers in patients with takotsubo syndrome (TTS).1
The association between TTS outcome and beta-blockers use is complex and multifactorial. In our registry, beta-blocker prescription at discharge was associated with the reduction of all-cause mortality, but not of TTS recurrence. One could interpret this result as the confirmation that beta-blockers do not have a significant effect in terms of preventing TTS recurrence, which is consistent with previous observational studies.2 ,3 Although we find a lower incidence of TTS recurrence between patients treated and non-treated with beta-blockers, we cannot exclude that our results were not statistically significant …
Contributors All authors contributed equally to this manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.