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Original research
Gender disparities in alcohol septal ablation for hypertrophic obstructive cardiomyopathy
  1. Dennis Lawin1,
  2. Thorsten Lawrenz1,2,
  3. Kristin Marx1,
  4. Nils Benedikt Danielsmeier1,
  5. Madan Raj Poudel1,
  6. Christoph Stellbrink1
  1. 1Cardiology and Intensive Care Medicine, University Hospital OWL of Bielefeld University, Campus Klinikum Bielefeld, Bielefeld, Germany
  2. 2Faculty of Health, University Witten Herdecke, Witten, Germany
  1. Correspondence to Dr Dennis Lawin, Cardiology and Intensive Care Medicine, University Hospital OWL of Bielefeld University, Campus Klinikum Bielefeld, D-33604, Bielefeld, Germany; dennis.lawin{at}klinikumbielefeld.de

Abstract

Objective Alcohol septal ablation (ASA) improves symptoms in hypertrophic obstructive cardiomyopathy (HOCM). We conducted a large retrospective analysis investigating gender effects on outcome after ASA.

Methods and results 1367 ASAs between 2002 and 2020 were analysed. Women (47.2%) were older (66.0 years (IQR 55.0–74.0) vs 54.0 years (IQR 45.0–62.0); p<0.0001) with more severe symptoms. The interventricular septal diameter (IVSD) was higher in men (21.0 mm (IQR 19.0–24.0) vs 20.0 mm (IQR 18.0–23.0); p<0.0001) but the IVSD indexed to body surface area was higher in women (10.9 mm/m2 (IQR 9.7–12.7) vs 10.2 mm/m2 (IQR 9.0–11.7); p<0.0001). Women had lower exercise-induced left ventricular outflow tract gradients (LVOTG) 1–4 days after ASA (55.0 mm Hg (IQR 30.0–109.0) vs 71.0 mm Hg (IQR 37.0–115.0); p=0.0006). There was a trend for lower resting LVOTG 1–4 days after ASA (20.0 mm Hg (IQR 12.0–37.5) vs 22.0 mm Hg (IQR 13.0–40.0); p=0.0062) and lower exercise-induced LVOTG after 6 months in women (34.0 mm Hg (IQR 21.0–70.0) vs 43.5 mm Hg (IQR 25.0–74.8); p=0.0072), but this was not statistically significant after Bonferroni correction. More women developed atrioventricular (AV) block (20.3% vs 13.3%; p=0.0005) and required a pacemaker (17.4% vs 10.4%; p=0.0002) but not a cardioverter defibrillator (9.0% vs 11.6% in men; p=n .s.). However, in multivariable regression models, there was no evidence that sex independently influenced LVOTG and the occurrence of AV block.

Conclusion Female patients with HOCM were older and had more advanced disease at the time of ASA. Women had superior short-term haemodynamic response to ASA but more often developed AV block after ASA. These results are important to consider for sex-specific counselling before ASA.

  • Cardiomyopathy, Hypertrophic

Data availability statement

All data relevant to the study are included in the article or uploaded as supplemental information.

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Data availability statement

All data relevant to the study are included in the article or uploaded as supplemental information.

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Footnotes

  • Twitter @DennisLawin

  • Contributors DL mainly performed the analysis, wrote the manuscript and, as the guarantor, he is responsible for the overall content. All coauthors contributed to the collection of data and analysis. The study was initiated and supervised by CS, who approved the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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