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Roadmap to a career in cardiogenetics
  1. Xaviar Michael Jones1,
  2. Eugenio Cingolani2
  1. 1Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
  2. 2Department of Cardiology, Electrophysiology Section, Cedars-Sinai Medical Center, Los Angeles, California, USA
  1. Correspondence to Dr Eugenio Cingolani, Department of Cardiology, Electrophysiology Section, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Eugenio.Cingolani{at}csmc.edu

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Groundbreaking discoveries in the human genome along with advances in nextgeneration sequencing (NGS) technologies made the study of inherited cardiovascular conditions (ICCs) more powerful than ever. The increased availability of genetic testing potentiates the opportunity of early detection of ICC, enabling a multidisciplinary genetic team to provide timely care to patients and families. Additionally, recent advances in gene modulation through sophisticated techniques set the stage for a new era in therapeutics and translatability from bench-to-bedside. Although the benefits of cardiogenetics are evident, most fellows receive neither scarce exposure nor acquisition of tools to assess risk potential of such diseases.1

Despite the absence of a standardised training curriculum, multiple pathways to a career in cardiogenetics coexist (figure 1).2 The heterogeneity and complexity of ICC demands acquaintance in diverse areas of cardiology, including arrhythmias, heart failure, cardiovascular imaging (echocardiography, CT, MRI), preventive cardiology and paediatric cardiovascular medicine.3 Essential competencies for clinical practice, such as interpretation of genetic test results and polygenic risk scores, genotype–phenotype correlations, construction of pedigrees and familiarity with …

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Footnotes

  • Twitter @XMichaelJonesMD, @EugenioCingolan

  • Contributors XMJ and EC contributed with manuscript draft and generation of figure. Both authors agree with the submitted version of the manuscript, take responsibility for the content of the entire manuscript and affirm that any queries related to any aspect of the same are appropriately managed.

  • Funding XMJ is supported by the National Institute of Health (NIH) T32 HL116273. Research in Dr Cingolani’s lab is funded by the NIH (RO1 HL135866 and RO1HL147570).

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.