Footnotes

• Twitter @vlgmrc

• Contributors AL conceived the original idea and wrote the first draft of the manuscript. MV critically revised the manuscript and gave final approval of the version to be published.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests MV reports grants and/or personal fees from AstraZeneca, Terumo, Alvimedica/CID, Abbott Vascular, Daiichi Sankyo, Bayer, CoreFLOW, Idorsia Pharmaceuticals, Universität Basel Department Klinische Forschung, Vifor, Bristol-Myers Squibb, Biotronik, Boston Scientific, Medtronic, Vesalio, Novartis, Chiesi, PhaseBio.

• Provenance and peer review Commissioned; internally peer reviewed.

• Author note References which include a * are considered to be key references.