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Heart failure and cardiomyopathies
Systematic review
Eosinophilic myocarditis: systematic review
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  • Published on: 23 November 2023
    The complexity of the association of eosinophilic myocarditis and COVID-19 infection

    Notwithstanding the fact that Blagova et al did not identify any specific findings related to eosinophilic myocarditis(EM) in their series of 14 patients with post-COVID myoendocarditis[1], anecdotal reports not cited by Techasatian et al[2] have documented an association between COVID 19 infection and eosinophilic myocarditis[3-5].
    Craver et al reported the case of a previously healthy 17 year old male who had a 2 day history of headache, nausea and vomiting , followed by sudden death. At autopsy his heart weighed 500 grams(expected weight fro age was 262-295 grams), with a histological profile characterised by an inflammatory infiltrate which had prominent" eosinophils, in addition to lymphocytes and macrophages. This was associated with multiple foci of myocyte necrosis.. Histological examination of the lungs revealed mild chronic inflammation of the bronchi with only occasional eosinophils. Postmortem nasopharyngeal swabs tested positive for SARS-2 CoV-2[3].
    In two other cases of the association of COVID-19 infection and eosinophilic myocarditis, each of the patients[4],[5] had a previous history of chronic asthma, thereby raising the possibility that eosinophilic myocarditis might have been a manifestation of eosinophilic granulomatosis with polyangiitis.
    However, given the fact that, in its own right, COVID-19 infection can be a trigger for eosinophilic pneumonia[6], the association of eosinophilic myocarditis and COVID-19 infectio...

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    Conflict of Interest:
    None declared.