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Management of pregnancy-related disorders to prevent future risk of coronary artery disease
  1. Mariyam O Sheidu1,
  2. Anandita Agarwala2,
  3. Suvasini Lakshmanan3,
  4. Michael C Honigberg4,
  5. Jared Alexander Spitz1,
  6. Garima Sharma5
  1. 1Inova Fairfax Heart and Vascular Institute, Fairfax, Virginia, USA
  2. 2Center for Cardiovascular Disease Prevention, Baylor Scott & White The Heart Hospital Baylor Plano, Plano, Texas, USA
  3. 3Cardiology, The Lundquist Institute, Torrance, California, USA
  4. 4Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
  5. 5Cardiology, Inova Fairfax Medical Campus, Falls Church, Virginia, USA
  1. Correspondence to Dr Garima Sharma, Cardiology, Inova Fairfax Medical Campus, Falls Church, VA 22042, USA; Garima.Sharma{at}inova.org

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Learning objectives

  • Recognise adverse pregnancy outcomes as sex-specific risk factors for future cardiovascular disease.

  • Incorporate the recommendations regarding cardiovascular screening and optimise cardiovascular risk factors across the pregnancy continuum.

  • Leverage the American Heart Association’s ‘Life’s Essential 8’ as a tool to assess cardiometabolic status and encourage mitigation of modifiable risk factors throughout the pregnancy windows.

Introduction

Ischaemic heart disease results in 7.5 million deaths worldwide and remains the leading cause of death in women.1 Additionally, pregnancy-related maternal morbidity in the world has increased nearly 200% between 1993 and 2014 in the USA.2 Adverse pregnancy outcomes (APOs), which include hypertensive disorders of pregnancy (HDPs), such as pre-eclampsia, gestational diabetes mellitus (GDM), preterm delivery and small-for-gestational-age infants, are common and occur in 17–20% of all pregnancies in the USA.3 Mounting evidence over the past several decades has demonstrated that a history of APOs robustly predicts later-life risk of cardiovascular disease (CVD), including coronary artery disease (CAD) and heart failure, in affected individuals.4 5 APOs and CVD share similar risk factors, including obesity, hypertension, metabolic syndrome, race and suboptimal social determinants of health (SDOHs).6

The American Heart Association’s (AHA) Life’s Essential 8 framework redefines cardiovascular health (CVH) and offers tools that clinicians should use to promote a healthy lifestyle to optimise cardiometabolic status throughout the pregnancy continuum.7 By increasing awareness of sex-specific risk factors, like APOs, across the different subgroups of women and screening these women for obstetric complications, we can identify women earlier who are at risk of future CVD. In doing so, we can initiate lifestyle interventions and, where appropriate, medical therapies sooner to prevent CAD.8

The burden of cardiovascular risk factors in pregnancy-capable populations needs better management and optimisation. Although the prevalence of ischaemic heart disease is increasing worldwide, the historical underestimation of CAD in women, combined …

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Footnotes

  • Twitter @AAgarwalaMD, @mchonig, @GarimaVSharmaMD

  • MOS and AA contributed equally.

  • Contributors MOS—conceptualisation of the topic, writing the manuscript and editing. AA—conceptualisation of the topic, writing the manuscript and editing. SL—conceptualisation of the topic and extensive editing of the manuscript. MCH—conceptualisation of the topic and extensive editing. JAS—conceptualisation of the topic and extensive editing. GS—conceptualisation of the topic, writing the manuscript and editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests MOS, AA and SL—none. MCH reports consulting fees from CRISPR Therapeutics and Comanche Biopharma, advisory board service for Miga Health and grant support from Genentech, all unrelated to the present work. Grant support from the National Heart, Lung, and Blood Institute (K08HL166687) and the American Heart Association (940166, 979465) given to GS (AHA 979462).

  • Provenance and peer review Commissioned; externally peer reviewed.

  • Author note References which include a * are considered to be key references.