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Research Article
Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods.
  1. J S Birkhead,
  2. E M Vaughan Williams

    Abstract

    Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug.

    https://doi.org/10.1136/hrt.39.6.657

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