Article Text
Abstract
A case of culture negative endocarditis complicated by immune complex glomerulonephritis and severe aortic regurgitation necessitated aortic valve replacement. Empirical treatment with penicillin and gentamicin according to UK guidelines was started. The pathogen, Streptococcus sanguis, was later identified by polymerase chain reaction amplification and sequencing of bacterial 16S ribosomal RNA. This molecular technique is likely to be of increasing importance in determining the aetiology of culture negative infective endocarditis, thus providing essential treatment and epidemiological information.
- endocarditis
- negative culture
- 16S rRNA
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Footnotes
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Source(s) of support (grants, equipment, drugs): none
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No competing interests to declare.
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Patient consent: We confirm that we have received written patient consent on the PMJ patient consent pro forma. This consent is dated 14 October 2004.
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