Article Text
Abstract
Objectives: To investigate the relation between aortic stiffness and coronary flow reserve (CFR) in patients with coronary artery disease (CAD).
Design: Observational study.
Setting: Coronary care unit of a primary care hospital.
Patients: 192 consecutive patients who underwent coronary angiography.
Main outcome measure: Brachial-ankle pulse wave velocity (ba-PWV), CFR, and severity of CAD.
Results: According to the angiographic findings, patients were divided into four subgroups: patients without significant stenosis (normal coronary artery (NCA) group, n = 28) and those with one vessel disease (1VD group, n = 92), two vessel disease (2VD group, n = 50), or three vessel disease (3VD group, n = 22). ba-PWV increased with the number of diseased vessels and was significantly correlated with the number of diseased vessels (NCA group v 1VD group v 2VD group v 3VD group: 1481 (252) v 1505 (278) v 1577 (266) v 1727 (347) cm/s, p < 0.001). CFR had a significant negative correlation with ba-PWV (r = −0.45, p < 0.0001). The diastolic to systolic velocity ratio obtained in 45 patients also was significantly correlated with ba-PWV (r = −0.35, p < 0.05). Multiple regression analysis showed that ba-PWV was an independent determinant of CFR (p < 0.01).
Conclusions: Coronary flow is altered with aortic stiffening in patients with CAD. These results suggest one possible mechanism for recent reports that aortic stiffness is a key cardiovascular risk factor.
- 1VD, one vessel disease
- 2VD, two vessel disease
- 3VD, three vessel disease
- ba-PWV, brachial-ankle pulse wave velocity
- BP, blood pressure
- CAD, coronary artery disease
- CFR, coronary flow reserve
- DSVR, diastolic to systolic velocity ratio
- NCA, normal coronary artery
- aortic stiffness
- coronary artery disease
- coronary circulation
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Footnotes
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Published Online First 10 October 2005
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There is no financial support in this study.
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There is no conflict in this study.