eLetters

215 e-Letters

published between 2004 and 2007

  • CRT Upgrade and Occurrence of Ventricular Arrhythmia
    John GF Cleland

    Dear Editor,

    Lin et al. report an observational study in 52 patients investigating whether upgrading an ICD, implanted predominantly for secondary prevention to CRT-D, can reduce arrhythmias.[1] They failed to detect an effect of CRT on arrhythmias during a mean follow up of 14 months. The CARE-HF extension study suggested that reduction in sudden death with CRT might be a late phenomenon occurring only after one...

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  • PFO Closure should be performed with ultrasound guidance
    Samir R. Kapadia

    Dear Editor,

    Dr. Wahl and colleagues studied the short and long- term safety and efficacy of percutaneous closure of patent foramen ovale (PFO) for prevention of paradoxical embolization using fluoroscopic guidance only (1). While we command their technical skills, we disagree that using fluoroscopy only is the safest and most efficient approach to percutaneous PFO closure. The authors correctly note that to dat...

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  • Antibiotic Prophylaxis to Prevent Infective Endocarditis should be given to Patients with...
    David R Ramsdale

    Antibiotic Prophylaxis to Prevent Infective Endocarditis should be given to Patients with Valvular or Structural Heart Disease Prior to Dental Treatment: Results of a National Survey Amongst UK Cardiologists and Cardiac Surgeons

    Dear Editor,

    Recently published guidelines suggesting that antibiotic prophylaxis (ABP) should not be given prior to dental treatment to patients with valvular or structural h...

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  • Saving lives means spending NHS resources effectively
    Michael R Chester

    Dear Editor,

    O'Flaherty and colleagues (1) have identified a worrying change in the hitherto improving CHD mortality data in England and Wales that has occurred despite record spending on coronary revascularisation. They correctly propose that the health intervention measures, as recommended by Wanless (2) and supported by the National Heart Forum (3) and NICE (4), should be urgently implemented in an attempt to p...

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  • Low EF: the best marker of poor prognosis in patients affected by non compaction
    Giovanni Fazio

    Dear Editor,

    McMahon et al reported in a recent article a reduction of TD velocities in children with noncompaction of the left ventricle, compared with normal controls. The authors concluded their work saying that the reduction of lateral mitral Ea velocity helps to predict children with LVNC who are at risk of adverse clinical outcomes including death and need for cardiac transplantation. In a precedent report...

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  • Rheumatoid factor and heart disease: supporting evidence regarding increased risk of mortality
    Craig J Currie

    Dear Editor,

    A recent study in Heart by Edwards and colleagues found an interesting association between rheumatoid factor (RF) and ischaemic heart disease [1]. We examined independently the related issue of the role of systemic inflammation in relation to clinical outcome in a forthcoming study [2]. This subsequent study reports an association between systemic inflammation, as measured by C-reactive protein (CRP...

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  • Yet Again Primary Percutaneous Coronary Intervention (PPCI) is the winner
    Manivannan Srinivasan

    Dear Editor,

    I read with interest, the recent original article by Nallamothu et al. The authors report higher 6-month mortality in both fibrinolysis and PPCI patients (p < 0.001 for both cohorts) with long treatment delays. For patients who received fibrinolytic therapy, 6-month mortality increased by 0.30% per 10-min delay in door-to-needle time between 30 and 60 min compared with 0.18% per 10-min delay in doo...

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  • Myocardial reduction of Gb3 content in Anderson-Fabry disease
    Cristina Chimenti

    Dear Editor,

    We read with interest the study by Hughes et al (1) that for the first time showed a reduction of Gb3 content in endomyocardial biopsy tissue of patients with Fabry cardiomyopathy after six months agalsidase alfa treatment.

    However, it should be point out that this study doesn’t demonstrate the efficacy of enzyme replacement therapy in clearing the Gb3 deposits from the cardiomyocytes, that i...

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  • Rheumatoid Factor-? Is it a biomarker of inflammation or an independent risk factor for IHD
    Manivannan Srinivasan

    Dear Editor,

    I read with interest the original article by Christopher J Edwards et al about the possibility of Rheumatoid factor being an independent risk factor for Ischaemic Heart Disease (1).The contribution of inflammation to the initiation and progression of coronary atherosclerosis is well established.I agree this study adds support to the importance of inflammation in atherosclerosis. The concept of autoimmunit...

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  • Percutaneous Coronary Interventions without on-site cardiac surgery standby: a word of caution
    Gianluigi Bisleri

    Dear Editor,

    We congratulate the work by Dr. Carlsson et al. about the safety of percutaneous coronary interventions(PCI) in an hospital with or without on-site cardiac surgery standby, albeit their study raises several concerns.

    First, the majority of patients(nearly 80%) had 1 or 2 vessels disease and as depicted in Table 2 only around 15% of patients had 2 or vessels treated. Arguably, no fundamental da...

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