eLetters

174 e-Letters

published between 2001 and 2004

  • Preconditioning: priming of the protonmotive force by ATP synthase reversal?
    Richard G Fiddian-Green

    Dear Editor

    We have reported that duodenal mucosa rapidly disposes of both acid and alkali in vitro; neither property being altered by gassing with N2 while iodoacetate was in the perfusing solutions. While acid disposal progressively decreased with time in complementary experiments with in vitro gut sacs, with in vivo gut sacs no fatigue was evident raising the possibility of an active component in the properti...

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  • Cardiac Maladaptation in athletes using anabolic steroides
    Erdem Kasikcioglu

    Dear Editor

    I read with great interest the published study by Urhausen et al. [1] It is known that anabolic steroid use in athletes has become a major medical issue. Although Urhausen et al. found that left ventricular wall thickness related to fat-free body mass did not differ between users and ex-users, Sachtleben et al. [2] previously reported that the parameters of left ventricular thickness showed si...

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  • Paradoxical Coronary Embolism - an Alternative explanation for increased cardiac troponin in acutePE
    Tsung O Cheng

    Dear Editor

    La Vecchia et al. [1] considered increased cardiac troponin on admission to be the strongest independent predictor of mortality in acute pulmonary embolism. They attributed the increased troponin to right ventricular involvement, because they excluded patients with known or prior coronary artery disease in their study. The criteria they used for exclusion were documented angina, previous myocardial...

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  • Platelet Activation and catheter intracoronary brachytherapy
    Fuad Lechin

    Dear Editor

    We read with great interest the article by Jaster et al. [1] dealing with the failure by aspirin and clopidogrel to inhibit platelet activation during vascular brachytherapy after percutaneous coronary intervention, which is responsible for a higher risk of stent thrombosis. With respect to the above, we would like to inform about some findings dealing with this issue.

    Platelet aggre...

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  • Preconditioning: might it reverse ATP synthase?
    Richard G Fiddian-Green

    Dear Editor

    The induction of ischaemia is accompanied by a fall in tissue pH. The fall is probably due to unreversed ATP hydrolysis rather than the accumulation of lactate. Stochiometric examination reveals that there is no net gain of protons during anaerobic glycolysis. Furthermore the degree of acidosis induced is not reduced by inhibiting glycolysis with iodoacetate and oxidative phosphorylation with KCN and ca...

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  • Maternal outcome of pregnancy following Mustard procedure
    David S Crossland

    Dear Editor

    We were interested to read Dr Thorne’s article on pregnancy in heart disease and have been developing our service locally for pregnancy in congenital heart disease.[1] We have been particularly concerned with the counselling and management of women following Mustard procedure as many of this unique group are now of child bearing age and there is little data as to their pregnancy outcome.[2]

    We...

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  • Re: Are the cardiac effects of anabolic steroid abuse in strength athletes reversible?
    Rob D. Dickerman, D.O., Ph.D

    Dear Editor

    I read the article by Urhausen et al. “Are the cardiac effects of anabolic steroid abuse in strength athletes reversible?” with great interest, however there are several factors that should be discussed.[1]

    First, the only subjects with left ventricular posterior wall measurements beyond normal limits were the users, which were only slightly enlarged >11.4 mm. We previously reported on...

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  • Re: Risk factors for non-fatal myocardial infarction in young South Asian adults
    Ayman J. Hammoudeh

    Dear Editor

    We read with great interest the paper by Ismail et al. on the risk factors for nonfatal myocardial infarction (AMI) in young South Asians adults.[1]

    The authors acknowledged they did not address two important risk factors, which we believe were significant omissions.
    1. The absence of analysis of AMI triggering events. In the West, 20-30% of AMI are triggered by...

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  • The French Paradox - The obsessing preoccupation about death certificates.
    Jean Ferrières

    Dear Editor

    The commentaries of Dr CF George are very interesting since they reveal the cultural gap in the redaction of death certificates on both sides of the Channel. The analysis of death certificates is a very relevant tool in general epidemiology and it seems that the tradition in anglo-saxon epidemiology has focused the physicians’ attention on a thorough and scrupulous redaction of the causes of death. As...

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  • Late Stent Thrombosis
    Barry F Uretsky

    Dear Editor

    Hayashi et al.[1] report two cases of acute myocardial infarction caused by thrombotic occlusion at a stent site two years after stenting.

    This report further supports the concept that there is a continuous risk for late stent thrombosis, a concept we described in our study of 1191 nonbrachytherapy patients undergoing coronary stenting and followed for 1 year after stent placement.[2] We...

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