eLetters

218 e-Letters

published between 2003 and 2006

  • Coeliac axis stenosis: risk factor for adverse outcome from acute myocardial infarction?
    Richard G Fiddian-Green

    Dear Editor,

    Kolkman et al (1), in the Dept. of Gastroenterology, Medisch Spectrum Twente, Enschede, The Netherlands, have established the value of gastric exercise tonometry in establishing the diagnosis of chronic splanchnic disease (CSD) and those with ischaemic complaints as having chronic splanchnic syndrome (CSS). [The practical details of exercise tonometry are reviewed in their excellent chapter on splan...

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  • Antithrombotic treatment in atrial fibrillation
    Oscar, M Jolobe

    Dear Editor,

    Given the fact that BAATAF conferred a relative risk reduction of 86%, and SPINAF conferred a relative risk reduction of 79% for embolic complications of non valvular atrial fibrillation(NVAF) utilising INR ranges of 1.5-2.7, and 1.4-2.8, respectively(1)(2), in a population presumably comprising, not only NVAF patients at high risk of embolic complications, but also those at low risk, the hypothesis...

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  • Use of nicotinic acid in JBS2
    Tony Patrikios

    Dear Editor,

    With interest we read the new JSB guidelines but would like to clarify an issue relating to the correct licensed indication for nicotinic acid. Table 11 of the guidelines specifies that nicotinic acid be used in severe hypertriglyceridaemia with prior acute pancreatitis or not responsive to fibrates. The only formulation of nicotinic acid licensed for the treatment of dyslipidaemia is the prolonged re...

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  • Possible interactions of air pollution and acute respiratory infections in the triggering of AMI
    Viktor Èuliæ

    Dear Editor,

    Respiratory tract infection has been implicated as a factor leading to the onset of acute myocardial infarction. In contrast to previous data,[1] Clayton et al.[2] did not observe a significant association between recent respiratory infection and myocardial infarction, but they did find a strong association of infarction with chest pain on breathing within the preceding week or with fever.

    In...

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  • Late stent thrombosis in Sirolimus stents - not as rare as one imagines!
    Austin Mohan Komaranchath

    Dear Editor,

    We recently came across a similar patient who had a Sirolimus eluting stent implanted in his LAD in June 2004 and returned to us with an anterior wall myocardial infarction on the 2nd of January 2006.He had taken Aspirin and Clopidogrel for 10 months and then had switched to lower dose Aspirin (150mg to 80 mg)and stopped the Clopidogrel. He developed symptoms of angina during a flight back to India from...

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  • Comment on heart analyses
    AD Tsakok

    Dear Editor,

    Biagini et al (1), Rodriguez et al (2) and Dursunglu et al (3) illustrate incorrect statistical analyses, by using the two-sample t-test. This compares normal means assuming unknown but equal variances. While the Central Limit Theorem justifies normality for mean inferences, making it unnecessary to test (3) for normality, unknown variances need not be homogeneous. This makes the two-sample t-test un...

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  • Dark chocolate and cardiovascular health
    Nir Barak

    Dear Editor,

    I read with great interest the letter by Hermann et al.[1] regarding dark chocolate and endothelial dysfunction. The authors conclude "a small daily treat of dark chocolate may substantially increase the amount of antioxidant intake and beneficially effect vascular health".

    Unfortunately, not many people are aware of the possible toxic effects of dark chocolate: apart from its content of flavan...

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  • Prognosis of patients with silent versus symptomatic myocardial ischemia
    Don Poldermans

    Dear Editor,

    We do appreciate Dr Tsakok's concern regarding the correct use of the two-sample-t-test. At our centre it is common use to apply the Kolmogorv-Smirnov test to test the normality assumption in all our analyses. In our study this test was not significant and therefore, we were allowed to use the parametric tests such as the two sample t-test. The method Dr Tsakok is proposing is unknown to us. We are not...

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  • In-stent restenosis: To stent or not to stent
    Peter Barlis

    Dear Editor,

    We read with interest the paper by Iofina et al.[1] highlighting the superior outcomes observed using sirolimus eluting stents (SES) versus intra-coronary radiation therapy (IRT) for patients with in-stent restenosis (ISR). This condition remains a significant source of morbidity and need for repeat procedures and, up until recently, IRT has remained the most proven treatment for ISR, with reported...

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  • Clopidogrel and atrial shunt closure for migraine: why is migraine aggravated immediately?
    Vinod K Gupta

    Dear Editor,

    Old medical theories, like myths, never die. In every era, long after the initial excitement evaporates, scientific theories that have not gathered logical strength through increasing clinical associations are recycled to address current perceptions. Such theories, like myths, offer a vicarious resolution of the ignorances that lies between our insecurities and our expectations.[1,2] Wilmshurst et al....

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