eLetters

174 e-Letters

published between 2001 and 2004

  • Beneficial Hemodynamic Effects Of Positive-pressure Ventilation In Patients With Heart Failure
    Mohamad Abdelsalam Abdelkader

    Dear Editor

    Positive-pressure ventilation may be associated with adverse cardiovascular effects, particularly when using large tidal volumes and / or high PEEP. The increased intra-thoracic pressure decreases venous return to the heart with subsequent reduction of cardiac filling, cardiac output and blood pressure. On the other hand, positive-pressure ventilation may have beneficial hemodynamic effects. If the pos...

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  • Leber Hereditary Optic Neuropathy and Hypertrophic Cardiomyopathy
    Juan Martínez L. de Letona

    Dear Editor

    Sorajja P et al. report a family harboring the mitochondrial DNA (mtDNA) A3460G mutation and showing a so far nondescribed association of Leber Hereditary Optic Neuropathy (LHON) and hypertrophic cardiomyopathy (HC).[1]

    In a revision of their experience, the authors highlight that the involvement of myocardium in patients with LHON is unusual and hypothesize whether the mtDNA A3460G m...

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  • Supraventricular tachycardia and elevated troponin in the absence of coronary artery disease
    Colin D Chue

    Dear Editor

    Reagarding the article by Collinson and Stubbs.[1]

    Background

    In their editorial of cardiac troponin, Collinson and Stubbs described its usefulness in diagnosis and predicting prognosis in patients with acute coronary syndromes.[1] They also summarised the conditions in which troponin may be elevated. This included rhythm disturbances such as prolonged tachyarrhythmia in the prese...

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  • Authors' reply: Platelet activation after VBT
    Markus Jaster

    Dear Editor

    We agree with the opinion of Krötz et al. that endothelial mediated or train source associated effects but not the irradiation itself lead to an increased platelet activation after VBT as pointed out by our publication.[1]

    In contrast to the paper of Krötz et al,[2] in which only relative changes in platelet activation are shown, our data were given as the percentages of act...

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  • Platelet activation associated with intracoronary brachytherapy
    Florian Krotz

    Dear Editor

    In the manuscript "Catheter based intracoronary brachytherapy leads to increased platelet activation" the authors observe an increased platelet activation as assessed by the activation markers CD63 (content of platelet lysosomes) and thrombospondin (content of platelet a-granules) immediately following intracoronary intervention. This occurred only when patients had received catheter-based irradiation...

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  • PLE after Fontan Operation and Immunological Dysfunction.
    Joseph Vettukattil

    Dear Editor

    The response by Prof Tarnok [1] is both interesting and thought provoking. The suggestion of mature immune system in this group will need further clarification. Thymectomy is often performed as part of their initial surgery; hence the nature of T cell response in this group may be different from other patients with PLE. This is further complicated by the presence of heterotaxy and asplenia. I have encoun...

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  • Re: Flecainide induced ventricular fibrillation in a neonate
    Shubhayan Sanatani

    Dear Editor

    I was disappointed to read the case report describing a catastrophic outcome in a neonate with an arrhythmia. While I agreed with each statement in the Discussion, the title suggested a direct causal relationship between the flecainide and ventricular fibrillation. In my opinion, this relationship was not proven, nor could it be.

    There are several important data not available in this case....

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  • Channel Gene Mutation (LQT) - a survival benefit?
    Friedrich Flachsbart

    Dear Editor

    Cystic Fibrosis is a channel mutation of palaeolithic Europe. Cystic Fibrosis made us tough to survive in the cold.

    What about LQT? Is it also a Caucasian mutation to survive post-streptococcal-carditis?

  • Does PLE after Fontan palliation refer to immunodeficiency?
    Attila Tarnok, Assoc. Prof., PhD

    Dear Editor

    We have read with great interest the manuscript by Chakrabarti et al.[1] on immunodeficiency in patients suffering from protein losing enteropathy (PLE) after Fontan palliation. The authors reported of lymphopenia and T-lymphocyte loss in two children with PLE. The infrequency of this syndrome and the even rarer immunological investigation of affected patients makes these observations very pre...

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  • The debate on public place defibrillators: no longer ill informed
    Michael C Colquhoun

    Dear Editor

    Pell considers the provision of AEDs in public places an inappropriate use of health service funding because at present there is a lack of evidence both of clinical effectiveness and cost effectiveness to support this strategy.[1]

    The basis for this assertion centres on the lack of clinical trials of the use of AEDs in this situation, or a lack of comparative or baseline data in published descript...

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