eLetters

174 e-Letters

published between 2001 and 2004

  • Arterial dysfunction contributes to 'beta-thalassaemia cardiomyopathy'
    YF Cheung

    Dear Editor

    Bosi and colleagues [1] suggested that significant volume load of the heart as a result of chronic anaemia in young adults with beta thalassaemia major is the main culprit of the so-called 'beta thalassaemic cardiomyopathy'. Their findings, based on echocardiographic assessment of left ventricular function, were similar to those reported previously.[2,3] Nonetheless, the role of arterial dysfunction in th...

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  • Genetic causes of phenotypic variation in monozygotic twins with hypertrophic cardiomyopathy
    Javed Ehtisham

    Dear Editor

    In the report by Palka et al,[1] and in previous such reports [2,3] the phenotypic variation seen in supposedly genetically identical monozygotic (MZ) twins with hypertrophic cardiomyopathy (HCM) is interpreted as a measure of the importance of environmental influences. However, although environmental factors undoubtedly contribute to the phenotype in HCM, there is substantial evidence that d...

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  • Authors reply to Kearney and Nolan: Predicting outcome in chronic heart failure
    Marcel L. Bouvy

    Dear Editor

    We do not agree that our study population was highly selected. The only exclusion criteria in our study were severe psychiatric problems and/or dementia, planned admission to a nursing home, not taking care of their own medication (e.g. filled or administered by relatives or district nurses) and/or life expectancy of less than 3 months. We feel that we sufficiently described the characteristics of our...

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  • Use of anticoagulation for non-valvar atrial fibrillation: comparison between two patient cohorts.
    Theofilos M. Kolettis

    Dear Editor

    We read with great interest the article recently published in "Heart" on the current use of anticoagulation for non-valvar atrial fibrillation [1].

    This article analyses the use of aspirin and anticoagulant treatment in 313 consecutive patients, presented with chronic atrial fibrillation of non-valvar etiology, in a single hospital in Northern Italy, from January 1 to June 30 2000. From th...

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  • Authors Reply to John Polito
    Gay Sutherland

    Dear Editor

    I thank John Polito for his lengthy reply to my article. I will try to discuss some of his points as far as I understand them.

    Firstly, no, my article is not a "commercial" for nicotine replacement! If anything it is a "commercial" for specialist psychological support. My intention was to present the data and these indicate that there is a role for both types of treatment for smokers. The data I...

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  • Neutrophils, Smoking and Coronary Heart Disease
    Petter Jaremo

    Dear Editor

    We read the recent published paper by Mueller and co-workers.[1] They demonstrate convincingly that the neutrophil count is a strong predictor for future coronary events in patients with acute coronary syndromes. Smoking habits, however, may to some extent confound their results.[2] To verify the assumption we want to publish this scientific note.

    Neutrophil granulocytes are a well-recogn...

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  • Response to Tammy M Vehige et al.
    John W G Yarnell

    Dear Editor

    In response to Tammy Vehige et al,[1] we had recognised that our findings may be controversial, but these were rigorously evaluated by ourselves and others before publication. However, to put it in context, it is one study amongst a particular population of healthy, middle-aged men of whom about 40% appeared to be doing enough vigorous intensity activity to confer cardiovascular benefit. The pape...

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  • Response to Dr Buckley
    John W G Yarnell

    Dear Editor

    In response to Dr Buckley [1] we agree that data on cardiovascular fitness would have been a useful addition to our study but resources in terms of staff and equipment precluded this possibility. In an ideal study, both cardiovascular fitness and questionnaire data would be obtained in parallel and in a long term cohort study habitual physical activity should be re-assessed at intervals.

    Refer...

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  • Dump NRT in favor of patient education!
    John R. Polito

    Dear Editor

    Is this abstract yet another nicotine commercial urging physicians to deprive patients of another of their diminishing windows of opportunity to begin allowing their reward pathways to sense the arrival of nicotine-free blood serum? I want to share a bit of contrary patient cessation counsel but first some background on why.

    I question this abstract's broad assertion that the "[use] of ...nicoti...

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  • Predicting outcome in chronic heart failure
    Mark T Kearney

    Dear Editor

    We read with interest the article by Bouvy and colleagues [1] and the accompanying editorial by Professor Cowie.[2] We would like to congratulate the investigators in attempting to construct a prognostic rule for patients with chronic heart failure. This is a neglected area in heart failure research.

    We have recently completed 5-year follow up of a study with the specific aim of identifying independe...

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