884 e-Letters

  • Effects of remote ischemic preconditioning on clinical outcomes after cardiac surgery
    Fu-Shan Xue

    In recent article of Candilio and colleagues assessing effect of remote ischemic preconditioning (RIPC) on postoperative outcomes in patients undergoing cardiac surgery, they showed that RIPC reduced amount of perioperative myocardial injury by 26% and incidence of acute kidney injury by 48%, respectively. They should be applauded for trying to control most of risk factors affecting postoperative myocardial and kidney in...

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  • The role of FFR in clinical practice
    Marco Araco

    Only recently the FAME-2 trial1 showed for the first time that, in patients with stable coronary artery disease (SCAD) and "significant" myocardial ischemia, there is a prognostic advantage of PCI over optimal medical therapy (OMT), and that this advantage is consistent in patients with either single or multi-vessel coronary artery disease. The clinical outcome of patients with coronary stenoses not associated with signi...

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    Inigo Lozano

    We have read with great interest the article written by Zhang et al[1] and we want to congratulate the authors on his contribution in this relevant issue. Since the first publication in 1995 by Pijls et al, fractional flow reserve has constantly progressed with undoubted success. After initially being validated as alternative to the non-invasive tests, the DEFER trial showed that a strategy of PCI based in FFR achieves b...

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  • Lower heart rate better in early AF
    Akshay k MEHTA

    Since the study shows a lower heart rate in paroxysmal or persistent AF is associated with lesser chance of progression to permanent AF, would rigorous treatment of heart rate with beta blockers in paroxysmal or persistent AF reduce the chance of their progression to permanent AF ?

    Conflict of Interest:

    None declared

  • Air pollution and cardiovascular disease
    Tomoyuki Kawada

    I read a paper by Xie et al. with interest (1). There is also a review article in the same issue by Chin on the mechanism on the relationship between air pollution and cardiovascular events (2), and expert position paper was also published (3). Xie et al. handled large samples in Beijing and conducted their survey with special emphasis on fine particulate matter (PM2.5) concentration and ischaemic heart disease (IHD) mo...

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  • Re:Comment on: An epidemiological appraisal of the association between heart rate variability and particulate air pollution: a meta-analysis
    Tim S. Nawrot

    We thank Buteau and colleague (Buteau et al. 2014) for their interest in our meta-analysis on Heart Rate Variability (HRV) and air pollution (Pieters et al. 2012). Their concern about combining studies from different types of regression models ignores the strength of our meta -analysis to combine all the available evidence on HRV and air pollution published before February 2012. Combining the available evidence is criti...

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  • Coffee brewing technique as a confounder in observational studies
    Christopher D Hingston

    Choi and colleagues describe an association between moderate coffee consumption and lower prevalence of subclinical coronary atherosclerosis [1]. This is consistent with a growing body of evidence that supports this finding. A similar large prospective study of over 400 000 participants, demonstrated that coffee consumption was inversley associated with both total and cause-specific mortality, specifically heart disease [...

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  • Paradoxical low-flow low-gradient aortic stenosis: advanced severe disease, a new entity or a progression of disease?
    Calvin WL Chin

    I read the research by Dahl et al. with great interest (1). The authors have suggested paradoxical low-flow low-gradient aortic stenosis is a distinct entity, and not an advanced stage of severe aortic stenosis. Indeed, they have observed only 5% of these patients had high-gradient severe disease prior to the index assessment (1).

    Recent studies have demonstrated that paradoxical low-flow low- gradient is a hete...

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  • Culprit or multivessel revascularisation in cardiogenic shock
    Georg Fuernau

    Georg Fuernau, Holger Thiele

    Medical Clinic II-Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center Luebeck, University of Luebeck, Luebeck, Germany

    Keywords: acute myocardial infarction, cardiogenic shock, multivessel percutaneous coronary intervention

    Corresponding author: Georg Fuernau, M.D. Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine)...

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  • Survival in South Asian and White European patients after acute myocardial infarction: new evidence of heterogeneity
    Raj S Bhopal

    Dear Editor Gholap et al confirmed a surprising observation that South Asians, compared to White British populations, have lower or similar, rather than higher mortality, following myocardial infarction, as Fischbacher et al first demonstrated in Scotland.(1;2) As the chief investigator of that Scottish study I found the result perplexing given South Asians' high prevalence of type 2 diabetes. A literature review showed...

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