TY - JOUR T1 - The reciprocal interaction between LV remodelling and allograft outcomes in kidney transplant recipients JF - Heart JO - Heart DO - 10.1136/heartjnl-2015-308142 SP - heartjnl-2015-308142 AU - Jung Nam An AU - Young Hoon Kim AU - Jun-Bean Park AU - Jin Ho Hwang AU - Kyung Don Yoo AU - Jae Yoon Park AU - Clara Tammy Kim AU - Hack-Lyoung Kim AU - Yong-Jin Kim AU - Duck-Jong Han AU - Chun Soo Lim AU - Yon Su Kim AU - Jung Pyo Lee Y1 - 2015/09/28 UR - http://heart.bmj.com/content/early/2015/09/28/heartjnl-2015-308142.abstract N2 - Objective This study aimed to investigate the incidence and related clinical factors of LV hypertrophy (LVH) regression after kidney transplantation and its effect on graft outcome.Methods Among the 3373 kidney transplant recipients who were enrolled in a multicentre cohort from 1997 to 2012, a total of 767 patients who underwent echocardiography before and after transplantation were included in this study followed for a median of 7.5 years.Results LVH regression steadily increased from 7.4% at 1 year to 35.4% at 5 years over the 5-year post-transplantation period. The probability of LVH regression decreased in the patients who received a kidney transplant due to end-stage renal disease of unknown aetiology (p=0.041) or who underwent pretransplant haemodialysis (p=0.020). The probability of LVH regression also decreased as the pretransplant LV mass index (p<0.001) and post-transplant systolic blood pressure increased (p=0.005). Conversely, LVH regression was significantly associated with the highest tertile of the pretransplant haemoglobin level (p=0.029). Furthermore, in the 5th year after transplantation, persistent LVH was independently associated with allograft failure (HR 1.95; 95% CI 1.14 to 3.33; p=0.015) and the LV mass index reliably predicted graft outcome.Conclusions LVH consistently regressed after kidney transplantation in most patients. Persistent LVH, low haemoglobin levels and elevated blood pressure were associated with an increased risk of allograft failure in kidney transplant recipients. ER -