%0 Journal Article %A Tamir Malley %A Vassilis Vassiliou %A Dominique Auger %A Claire Raphael %A Helen Berry %A Eva Nyktari %A Francisco Alpendurada %A Jackie Donovan %A Dudley Pennell %A Sanjay Prasad %T 158 NT-pro BNP and Survival in Aortic Stenosis %D 2016 %R 10.1136/heartjnl-2016-309890.158 %J Heart %P A113-A114 %V 102 %N Suppl 6 %X Introduction Elevated NT-pro BNP is associated with worse outcome in patients with cardiomyopathy.Hypothesis We hypothesized that a mild elevation in NT-pro BNP may be associated with a worse outcome in patients with Aortic Stenosis (AS).Methods Between 2011 and 2015, consecutive consenting patients with moderate (1.0–1.5 cm2) or severe (<1 cm2) AS considered for aortic valve intervention (either for severe AS or moderate AS with coronary disease) who had a cardiovascular magnetic resonance (CMR) scan undertaken for anatomy and function and also had blood stored for biomarker analysis were included. NT-pro BNP was measured using one-step immunoassay sandwich method with a final fluorescent detection (ELFA). Survival was obtained from hospital notes, electronic records and the National Strategic Office.Results 112 patients (76 ± 10 years, 78 male) were included. The group was dichotomised according to NT-pro BNP value, into normal NT-pro BNP value group (values from 0–300 pg/ml, 23 patients) and high group (>300 pg/ml, 89 patients). End point was all cause mortality. At a median of 12 months follow-up, 21 patients had died, all from the high NT-pro BNP group. The high NT-pro BNP group had significantly worse prognosis hazard ratio=3.6 (95% CI=1.24–10.44, p = 0.00184). Although the NT-pro BNP correlated with LVEF its association with outcome was independent of this.Conclusions In a prospective mixed cohort of patients with AS undergoing investigations for consideration of aortic valve intervention, even a mild elevation in NT-pro BNP is associated with worse short term outcome. This can be taken into consideration regarding timing of intervention especially in the asymptomatic population.Abstract 158 Figure 1 Survival in low and high NT - Pro BNP groups %U https://heart.bmj.com/content/heartjnl/102/Suppl_6/A113.2.full.pdf