RT Journal Article
SR Electronic
T1 The impact of moderate distance recreational running and ageing on cardiac physiology
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 219
OP 226
DO 10.1136/heartjnl-2016-310059
VO 103
IS 3
A1 Jonathan H Kim
A1 Yi-An Ko
A1 Jeff Hedley
A1 James MacNamara
A1 Mosaab Awad
A1 William Taylor
A1 Sean Healy
A1 Hiroshi Aida
A1 Ngoc-Anh Le
A1 Peter W Wilson
A1 Melissa White
A1 Laurence S Sperling
A1 Joseph S Wilson, Jr
A1 Aaron L Baggish
YR 2017
UL http://heart.bmj.com/content/103/3/219.abstract
AB Objective Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown.Methods 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18–20 years old, N=19); group 2 (45–50 years old, N=27); group 3 (70–75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race.Results Despite age-dependent baseline differences in ventricular size and diastolic tissue velocities, there were no significant within group or across group decrements in ventricular systolic or diastolic function following race completion. Postrace increases in cardiac troponin-I (cTnI), B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) were common and demonstrated distinct age dependent profiles. Specifically, BNP increases were most pronounced among older runners (group 3Δ: 16±22 pg/mL, p=0.001), hs-CRP increased only among younger runners (group 1Δ: 1.5±2.7 mg/L, p=0.03) and cTnI increased in both younger (group 1Δ: 0.01±0.02 ng/mL, p=0.028) and older (group 3Δ: 0.01±0.01 ng/mL, p=0.007) runners, but not middle aged runners (group 2Δ: 0.00±0.00 ng/mL, p=0.57).Conclusions Moderate distance recreational running leads to distinct age-dependent biomarker release but is not associated with cardiac fatigue, a proposed stimulus for pathologic cardiac remodelling that has been observed following longer distance running events.