RT Journal Article
SR Electronic
T1 Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 383
OP 389
DO 10.1136/heartjnl-2015-309217
VO 103
IS 5
A1 Magnus J Hagnäs
A1 Timo A Lakka
A1 Sudhir Kurl
A1 Rainer Rauramaa
A1 Timo H Mäkikallio
A1 Kai Savonen
A1 Jari A Laukkanen
YR 2017
UL http://heart.bmj.com/content/103/5/383.abstract
AB Objective The aim of this study was to investigate whether information on both cardiorespiratory fitness (CRF) and exercise-induced ST segment depression improves the prediction of sudden cardiac death (SCD) in men.Methods The study was based on a population sample of 2328 men aged 42–60 years, who were followed up for on average 19 years. CRF was assessed with maximal exercise test using respiratory gas analysis, expressed in metabolic equivalents (METs) and dichotomised at eight METs. Exercise-induced ST segment depression was defined as 1 mm ST segment depression in ECG.Results Altogether 165 SCDs occurred during the follow-up. Men with low CRF (<8 METs) and exercise-induced ST segment depression had 4.8-fold (95% CI 2.9 to 7.9) higher risk of SCD than men with high CRF and without exercise-induced ST segment depression (p=0.013 for interaction) after adjustment for other cardiovascular risk factors. Men with high CRF and exercise-induced ST segment depression did not have a statistically significantly higher risk of SCD (HR 1.9, 95% CI 0.9 to 3.8) than men with high CRF and without exercise-induced ST segment depression.Conclusions The combination of low CRF and exercise-induced ST segment depression was associated with a markedly increased risk of SCD in men.