RT Journal Article SR Electronic T1 Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at ID2 JF Heart JO Heart FD BMJ Publishing Group Ltd and British Cardiovascular Society SP heartjnl-2017-312045 DO 10.1136/heartjnl-2017-312045 A1 Amanda A Seyerle A1 Henry J Lin A1 Stephanie M Gogarten A1 Adrienne Stilp A1 Raul Méndez Giráldez A1 Elsayed Soliman A1 Antoine Baldassari A1 Mariaelisa Graff A1 Susan Heckbert A1 Kathleen F Kerr A1 Charles Kooperberg A1 Carlos Rodriguez A1 Xiuqing Guo A1 Jie Yao A1 Nona Sotoodehnia A1 Kent D Taylor A1 Eric A Whitsel A1 Jerome I Rotter A1 Cathy C Laurie A1 Christy Avery YR 2017 UL http://heart.bmj.com/content/early/2017/11/09/heartjnl-2017-312045.abstract AB Objective PR interval (PR) is a heritable electrocardiographic measure of atrial and atrioventricular nodal conduction. Changes in PR duration may be associated with atrial fibrillation, heart failure and all-cause mortality. Hispanic/Latino populations have high burdens of cardiovascular morbidity and mortality, are highly admixed and represent exceptional opportunities for novel locus identification. However, they remain chronically understudied. We present the first genome-wide association study (GWAS) of PR in 14 756 participants of Hispanic/Latino ancestry from three studies.Methods Study-specific summary results of the association between 1000 Genomes Phase 1 imputed single-nucleotide polymorphisms (SNPs) and PR assumed an additive genetic model and were adjusted for global ancestry, study centre/region and clinical covariates. Results were combined using fixed-effects, inverse variance weighted meta-analysis. Sequential conditional analyses were used to identify independent signals. Replication of novel loci was performed in populations of Asian, African and European descent. ENCODE and RoadMap data were used to annotate results.Results We identified a novel genome-wide association (P<5×10−8) with PR at ID2 (rs6730558), which replicated in Asian and European populations (P<0.017). Additionally, we generalised 10 previously identified PR loci to Hispanics/Latinos. Bioinformatics annotation provided evidence for regulatory function in cardiac tissue. Further, for six loci that generalised, the Hispanic/Latino index SNP was genome-wide significant and identical to (or in high linkage disequilibrium with) the previously identified GWAS lead SNP.Conclusions Our results suggest that genetic determinants of PR are consistent across race/ethnicity, but extending studies to admixed populations can identify novel associations, underscoring the importance of conducting genetic studies in diverse populations.