PT  - JOURNAL ARTICLE
AU  - Gu, Sophie Zhaotao
AU  - Batty, Jonathan
AU  - Jordan, Rebecca
AU  - Veerasamy, Murugapathy
AU  - Sinclair, Hannah
AU  - Bagnall, Alan
AU  - Das, Rajiv
AU  - Spyridopoulos, Ioakim
AU  - Egred, Mohaned
AU  - Zaman, Azfar
AU  - Purcell, Ian
AU  - Edwards, Richard
AU  - Ahmed, Javed
AU  - Kunadian, Vijay
TI  - 27 The association of frailty and coronary artery disease burden in older patients with non-st elevation acute coronary syndrome
AID  - 10.1136/heartjnl-2017-BCIS.27
DP  - 2017 Dec 01
TA  - Heart
PG  - A12--A12
VI  - 103
IP  - Suppl 7
4099  - http://heart.bmj.com/content/103/Suppl_7/A12.1.short
4100  - http://heart.bmj.com/content/103/Suppl_7/A12.1.full
SO  - Heart2017 Dec 01; 103
AB  - Introduction Frailty is common in older patients who present with Acute Coronary Syndrome (ACS). However, its association with coronary disease complexity measured by Syntax and British Cardiovascular Intervention Society jeopardy score (BCIS JS) is not known.Methods 276 patients ≥75 years of age, admitted for invasive management of Non-ST Elevation ACS (NSTEACS), were enrolled into a 2 centre prospective observational study (ICON1 study-NCT01933581). Frailty was assessed using the Fried criteria (score 0 robust, 1 or 2 pre-frail and ≥3 is frail). Syntax 1.0 calculator, BCIS algorithm and Global Registry of Acute Coronary Events (GRACE) 2.0 calculator were used to calculate scores. Procedure complication includes dissection, distal embolization, abrupt closure, thrombus, perforation and loss of side branch evaluated at Newcastle angiographic core lab.Results Frail patients tend to have higher GRACE 2.0 scores (124.0±13.7 vs 131.3±19.7 vs 136.0±19.5, p=0.008). With increasing frailty, there was a non-significant increase in the proportion with SYNTAX score greater than 22 (20.8% vs 27.5% vs 31.5%, p=0.436) and BCIS JS ≥6 (56.0% vs 61.6% vs 64.1%, p=0.651). Frail patients were more likely to have moderate to severe calcification (34% vs 44.8% vs 62.0%, p=0.005). Overall procedure complication rate is low at 4.6%, with no difference among frailty groups (2.3% vs 4.5% vs 6.3%, p=0.76).View this table:Abstract 27 Table 1 Baseline characteristics by fried frailty statusConclusions Frail older patients have higher GRACE score and more severe calcification in the coronary arteries. However, the complexity of coronary disease is not significantly different in this patient group.