PT  - JOURNAL ARTICLE
AU  - Sophie Zhaotao Gu
AU  - Hannah Sinclair
AU  - James Latimer
AU  - Jonathan Batty
AU  - Alan Bagnall
AU  - Ian Purcell
AU  - Rajiv Das
AU  - Ioakim Spyridopoulos
AU  - Richard Edwards
AU  - Azfar Zaman
AU  - Mohaned Egred
AU  - Javed Ahmed
AU  - Gary S Mintz
AU  - Vijay Kunadian
TI  - 11 The association of frailty and coronary artery plaque composition in high-risk older patients with non-st elevation acute coronary syndrome
AID  - 10.1136/heartjnl-2017-BCIS.11
DP  - 2017 Dec 01
TA  - Heart
PG  - A6--A6
VI  - 103
IP  - Suppl 7
4099  - http://heart.bmj.com/content/103/Suppl_7/A6.1.short
4100  - http://heart.bmj.com/content/103/Suppl_7/A6.1.full
SO  - Heart2017 Dec 01; 103
AB  - Introduction The association of frailty with vulnerable plaques and plaque composition in older patients following non-ST elevation acute coronary syndrome (NSTEACS) is not known.Methods 27 patients>70 years of age, admitted for invasive management of NSTEACS enrolled in the prospective observational ICON1 study, had Optical Coherence Tomography (OCT, St. Jude, Minneapolis, MN, USA) performed in all 3 coronary arteries. Frailty was assessed using the Fried criteria (score 0=robust, 1 or 2=pre frail and ≥3 is frail). OCT analyses were performed by QIvus 3.0 (Medis medical imaging systems, Leiden) at Newcastle University Angiography/IVUS/OCT Core Laboratory.% plaque composition (number of component [lipid, calcium, etc.,] frames/number of lesion frames×100) and presence of thin cap fibroatheroma (TCFA) and other OCT parameters are reported. The ICON1 study protocol is previously published.Results There were 8 (29.6%) robust, 14 (51.9%) pre-frail, and 5 (18.5%) frail patients. Mean age was 80.2±3.9 years, and 16 (59.3%) patients were male. Total length imaged was 75.3±31.1 mm and total OCT frames analysed were 348±155/patient. TCFA was present in the culprit artery in 9 (33%) patients and 6 (22.2%) patients had a non-culprit artery TCFA; thus, overall 11 (40.7%) had at least one TCFA in their coronary arteries. There is no significant difference in plaque composition between frailty groups (table 1).View this table:Abstract 11 Table 1 OCT measurements by fried frailty statusConclusions In this selected high risk older patients presenting with NSTEACS, there was no difference in the coronary artery plaque composition or presence of high risk plaque among the frailty groups as evaluated using OCT.