RT Journal Article SR Electronic T1 Influence of arterial stiffness on cardiovascular outcome in patients without high blood pressure JF Heart JO Heart FD BMJ Publishing Group Ltd and British Cardiovascular Society SP 318 OP 323 DO 10.1136/heartjnl-2017-311751 VO 104 IS 4 A1 Keishi Ichikawa A1 Satoru Sakuragi A1 Takahiro Nishihara A1 Masahiro Tsuji A1 Atsushi Mori A1 Fumi Yokohama A1 Tadashi Wada A1 Daiji Hasegawa A1 Kenji Kawamoto A1 Machiko Tanakaya A1 Yusuke Katayama A1 Hiroshi Ito YR 2018 UL http://heart.bmj.com/content/104/4/318.abstract AB Objective Although blood pressure (BP) is a major determinant of arterial stiffness, whether high pulse wave velocity (PWV) adversely influences cardiac parameters and cardiovascular (CV) outcome in patients without high BP remains unclear.Methods Outpatients without high BP (n=320), defined as systolic BP ≥140 mm Hg, were enrolled in this retrospective study. At baseline, all patients underwent echocardiography and multidetector CT to determine the coronary artery calcification (CAC) score. Arterial stiffness was assessed based on brachial-ankle PWV (baPWV), from which patients were classified into two groups: those with high (≥18 m/s, n=89) and low baPWV (<18 m/s, n=231). Cardiac parameters and CV event incidence during the follow-up period were compared between these groups.Results In multivariable linear regression analysis, baPWV was significantly associated with CAC score and serum N-terminal pro-brain natriuretic peptide hormone level, after adjustment for confounding factors. In multivariable logistic regression analysis, baPWV ≥18 m/s was significantly associated with CAC score ≥400 (OR 2.466, 95% CI 1.012 to 6.009, p=0.0471). Kaplan-Meier analysis showed that the high-baPWV group experienced more CV events during the 575 days of follow-up (20% vs 6%, p=0.0003).Conclusions High baPWV was associated with greater CAC and a high risk of a future CV event, especially coronary artery disease, even in patients without high BP.