RT Journal Article
SR Electronic
T1 Cardiopulmonary fitness in children with congenital heart diseases versus healthy children
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1026
OP 1036
DO 10.1136/heartjnl-2017-312339
VO 104
IS 12
A1 Pascal Amedro
A1 Arthur Gavotto
A1 Sophie Guillaumont
A1 Helena Bertet
A1 Marie Vincenti
A1 Gregoire De La Villeon
A1 Charlène Bredy
A1 Philippe Acar
A1 Caroline Ovaert
A1 Marie-Christine Picot
A1 Stefan Matecki
YR 2018
UL http://heart.bmj.com/content/104/12/1026.abstract
AB Objective We aimed to compare the cardiopulmonary fitness of children with congenital heart diseases (CHD) with that of age-adjusted and gender-adjusted controls. We also intended to identify clinical characteristics associated with maximum oxygen uptake (VO2max) in this population.Methods and results We included in a cross-sectional multicentre study a total of 798 children (496 CHD and 302 controls) who underwent a complete cardiopulmonary exercise test (CPET). The association of clinical characteristics with VO2max was studied using a multivariate analysis. Mean VO2max in the CHD group and control represented 93%±20% and 107%±17% of predicted values, respectively. VO2max was significantly lower in the CHD group, overall (37.8±0.3vs 42.6±0.4 mL/kg/min, P<0.0001) and for each group (P<0.05). The mean VO2max decline per year was significantly higher in CHD than in the controls overall (−0.84±0.10 vs −0.19±0.14 mL/kg/min/year, P<0.01), for boys (−0.72±0.14vs 0.11±0.19 mL/kg/min/year, P<0.01) and for girls (−1.00±0.13 vs −0.55±0.21 mL/kg/min/year, P=0.05). VO2max was associated with body mass index, ventilatory anaerobic threshold, female gender, restrictive ventilatory disorder, right ventricle systolic hypertension, tricuspid regurgitation, the number of cardiac catheter or surgery procedures, and the presence of a genetic anomaly.Conclusions Although the magnitude of the difference was not large, VO2max among children with CHD was significantly lower than in normal children. We suggest performing CPET in routine follow-up of these patients.Trial registration number ClinicalTrials.gov NCT01202916; Post-results.