RT Journal Article SR Electronic T1 Influence of myocardial scar on the response to frequent premature ventricular complex ablation JF Heart JO Heart FD BMJ Publishing Group Ltd and British Cardiovascular Society SP 378 OP 383 DO 10.1136/heartjnl-2018-313452 VO 105 IS 5 A1 Diego Penela A1 Mikel Martínez A1 Juan Fernández-Armenta A1 Luis Aguinaga A1 Luis Tercedor A1 Augusto Ordóñez A1 Juan Acosta A1 Julio Martí-Almor A1 Felipe Bisbal A1 Luca Rossi A1 Roger Borràs A1 Markus Linhart A1 David Soto-Iglesias A1 Beatriz Jáuregui A1 José T Ortiz-Pérez A1 Rosario J Perea A1 Xavier Bosch A1 Lluis Mont A1 Antonio Berruezo YR 2019 UL http://heart.bmj.com/content/105/5/378.abstract AB Objective This study aims to evaluate the influence of myocardial scar after premature ventricular complexes (PVC) ablation in patients with left ventricular (LV) dysfunction.Methods 70 consecutive patients (58±11 years, 58 (83%) men, 23% (18–32) mean PVC burden) with LV dysfunction and frequent PVCs submitted for ablation were included. A late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) was performed prior to the ablation and a quantitative and qualitative analysis of the scar was done.Results Left ventricular ejection fraction progressively improved from 34.3%±9% at baseline to 44.4%±12% at 12 months (p<0.01) and 48 (69%) patients were echocardiographic responders. New York Heart Association class improved from 1.96±0.9 points at baseline to 1.36±0.6 at 12 months (p<0.001). Brain natriuretic peptide decreased from 120 (60–284) to 46 (23–81) pg/mL (p=0.04). Twenty-nine (41%) patients showed scar in the preprocedural LGE-CMR with a mean scar mass of 10.4 (5–20) g. Mean scar mass was significantly smaller in responders than in non-responders (0 (0–4.7) g vs 2 (0–14) g, respectively, p=0.017). PVC burden reduction (OR 1.09 (1.01–1.16), p=0.02) and scar mass (OR 0.9 (0.81–0.99), p=0.04) were independent predictors of response, but the former showed a higher accuracy.Conclusions Presence of myocardial scar modulates, but does not preclude, the probability of response to PVC ablation in patients with LV dysfunction.