TY - JOUR T1 - Cardiac implantable electronic devices in adults with tetralogy of Fallot JF - Heart JO - Heart SP - 538 LP - 544 DO - 10.1136/heartjnl-2018-314072 VL - 105 IS - 7 AU - Alexander C Egbe AU - William R Miranda AU - Malini Madhavan AU - Naser M Ammash AU - Venkata R Missula AU - Mohammed Al-Otaibi AU - Ayotola Fatola AU - Srikanth Kothapalli AU - Heidi M Connolly Y1 - 2019/04/01 UR - http://heart.bmj.com/content/105/7/538.abstract N2 - Background Tachyarrhythmias and bradyarrhythmias affect 20%–50% of adult patients with tetralogy of Fallot (TOF) and some of these patients will require cardiac implantable electronic devices (CIED) such as pacemaker and/or internal cardioverter defibrillator.Methods The Mayo Adult Congenital Heart Disease database was queried for patients with repaired TOF and history of CIED implantation, 1990–2017. The study objectives were: (1) determine the occurrence of device-related complications defined as lead failure, lead recall, device infection and lead thrombus; and (2) determine the occurrence and risk factors for defibrillator shock.Results There were 99 patients (age 46±14 years and 66 (66%) men) with CIED, and the CIEDs were 41 (41%) pacemakers and 73 (73%) defibrillators. Indication for defibrillator implantation was for primary prevention in 28 (38%) and secondary prevention in 45 (62%). Device-related complications occurred in 20 (20%) patients (lead failure 17, lead recall 4, device infection 12 and thrombus 3). Twenty-five per cent of all device infections occurred within 30 days from the time of device generator change. Annualised rates of appropriate and inappropriate shocks were 5.7% and 6.2%, respectively. The use of class III antiarrhythmic drug was protective against defibrillator shock.Conclusion The current study provides useful outcome data to aid patient counselling and clinical decision-making. Further studies are required to explore ways to decrease the risk of postprocedural infection after device generator change, and to determine which patients will benefit from empirical antiarrhythmic therapy as a strategy to decrease incidence of inappropriate defibrillator shock. ER -