RT Journal Article SR Electronic T1 Grip strength predicts cardiac adverse events in patients with cardiac disorders: an individual patient pooled meta-analysis JF Heart JO Heart FD BMJ Publishing Group Ltd and British Cardiovascular Society SP 834 OP 841 DO 10.1136/heartjnl-2018-313816 VO 105 IS 11 A1 Rita Pavasini A1 Matteo Serenelli A1 Carlos A Celis-Morales A1 Stuart R Gray A1 Kazuhiro P Izawa A1 Satoshi Watanabe A1 Eloisa Colin-Ramirez A1 Lilia Castillo-Martínez A1 Yasuhiro Izumiya A1 Shinsuke Hanatani A1 Yoshiro Onoue A1 Kenichi Tsujita A1 Peter S Macdonald A1 Sunita R Jha A1 Véronique L Roger A1 Sheila M Manemann A1 Juan Sanchis A1 Vicente Ruiz A1 Giulia Bugani A1 Elisabetta Tonet A1 Roberto Ferrari A1 Stefano Volpato A1 Gianluca Campo YR 2019 UL http://heart.bmj.com/content/105/11/834.abstract AB Objective Grip strength is a well-characterised measure of weakness and of poor muscle performance, but there is a lack of consensus on its prognostic implications in terms of cardiac adverse events in patients with cardiac disorders.Methods Articles were searched in PubMed, Cochrane Library, BioMed Central and EMBASE. The main inclusion criteria were patients with cardiac disorders (ischaemic heart disease, heart failure (HF), cardiomyopathies, valvulopathies, arrhythmias); evaluation of grip strength by handheld dynamometer; and relation between grip strength and outcomes. The endpoints of the study were cardiac death, all-cause mortality, hospital admission for HF, cerebrovascular accident (CVA) and myocardial infarction (MI). Data of interest were retrieved from the articles and after contact with authors, and then pooled in an individual patient meta-analysis. Univariate and multivariate logistic regression was performed to define predictors of outcomes.Results Overall, 23 480 patients were included from 7 studies. The mean age was 62.3±6.9 years and 70% were male. The mean follow-up was 2.82±1.7 years. After multivariate analysis grip strength (difference of 5 kg, 5× kg) emerged as an independent predictor of cardiac death (OR 0.84, 95% CI 0.79 to 0.89, p<0.0001), all-cause death (OR 0.87, 95% CI 0.85 to 0.89, p<0.0001) and hospital admission for HF (OR 0.88, 95% CI 0.84 to 0.92, p<0.0001). On the contrary, we did not find any relationship between grip strength and occurrence of MI or CVA.Conclusion In patients with cardiac disorders, grip strength predicted cardiac death, all-cause death and hospital admission for HF.Trial registration number CRD42015025280.