TY - JOUR T1 - Low systemic arterial compliance is associated with increased cardiovascular morbidity and mortality in aortic valve stenosis JF - Heart JO - Heart SP - 1507 LP - 1514 DO - 10.1136/heartjnl-2018-314386 VL - 105 IS - 19 AU - Edda Bahlmann AU - Dana Cramariuc AU - Sahrai Saeed AU - John B Chambers AU - Christoph A Nienaber AU - Karl-Heinz Kuck AU - Mai Tone Lønnebakken AU - Eva Gerdts Y1 - 2019/10/01 UR - http://heart.bmj.com/content/105/19/1507.abstract N2 - Objective Lower systemic arterial compliance (SAC) is associated with increased cardiovascular morbidity and mortality in hypertension, but this has not been assessed in a prospective study in aortic valve stenosis (AS).Methods Data from 1641 patients (38% women) with initially asymptomatic mild-moderate AS enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study was used. Median follow-up was 4.3 years. SAC was assessed from Doppler stroke volume index to central pulse pressure ratio and considered low if ≤0.64 mL/m², corresponding to the lower tertile in the population. The association of SAC with outcome was assessed in Cox regression analysis and reported as HR and 95% CI.Results Low SAC at baseline was characterised by older age, female sex, hypertension, obesity, presence of a small aortic root, lower mean aortic gradient and more severe AS by effective aortic valve area (all p<0.01). In Cox regression analysis adjusting for factors, low SAC was associated with higher HRs for cardiovascular death (HR 2.13(95% CI 1.34 to 3.40) and all-cause mortality (HR 1.71(95% CI 1.23 to 2.38)), both p=0.001). The results did not change when systolic or diastolic blood pressure, other measures of AS severity or presence of discordantly graded AS were included in subsequent models. Presence of low SAC did not improve mortality prediction in reclassification analysis.Conclusions In patients with AS without diabetes and known cardiovascular disease, but a high prevalence of hypertension, low SAC was associated with higher cardiovascular and all-cause mortality independent of well-known prognosticators.Trial registration number NCT00092677; Post-results. ER -