RT Journal Article
SR Electronic
T1 Long-term prognosis of patients with J-wave syndrome
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 299
OP 306
DO 10.1136/heartjnl-2019-315007
VO 106
IS 4
A1 Tsukasa Kamakura
A1 Tetsuji Shinohara
A1 Kenji Yodogawa
A1 Nobuyuki Murakoshi
A1 Hiroshi Morita
A1 Naohiko Takahashi
A1 Yasuya Inden
A1 Wataru Shimizu
A1 Akihiko Nogami
A1 Minoru Horie
A1 Takeshi Aiba
A1 Kengo Kusano
YR 2020
UL http://heart.bmj.com/content/106/4/299.abstract
AB Objective Limited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF).Methods This was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardioverter defibrillator. All patients had a history of VF. All patients with ERS underwent drug provocation testing with standard and high intercostal ECG recordings to rule out BrS. The impact of global J waves (type 1 ECG or anterior J waves and inferolateral J waves in two or more leads) on the prognosis was evaluated.Results During the 91±66 months of the follow-up period, 52 (39%) patients (BrS: 37; ERS: 15) experienced recurrence of VF. Patients with BrS and ERS with global J waves showed a significantly higher incidence of VF recurrence than those without (BrS: log-rank, p=0.014; ERS: log-rank, p=0.0009). The presence of global J waves was a predictor of VF recurrence in patients with JWS (HR: 2.16, 95% CI 1.21 to 3.91, p=0.0095), while previously reported high-risk electrocardiographic parameters (high-amplitude J waves ≥0.2 mV and J waves associated with a horizontal or descending ST segment) were not predictive of VF recurrence.Conclusions This multicentre long-term study showed that the presence of global J waves was associated with a higher incidence of VF recurrence in patients with JWS.