RT Journal Article
SR Electronic
T1 Gamma-glutamyl transferase variability and the risk of hospitalisation for heart failure
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1080
OP 1086
DO 10.1136/heartjnl-2019-316271
VO 106
IS 14
A1 So-hyeon Hong
A1 Ji Sung Lee
A1 Jung A Kim
A1 You-Bin Lee
A1 Eun Roh
A1 Ji Hee Yu
A1 Nam Hoon Kim
A1 Hye Jin Yoo
A1 Ji A Seo
A1 Sin Gon Kim
A1 Nan Hee Kim
A1 Sei Hyun Baik
A1 Kyung Mook Choi
YR 2020
UL http://heart.bmj.com/content/106/14/1080.abstract
AB Objective Gamma-glutamyl transferase (GGT) is associated with oxidative stress, inflammation, cardiovascular disease and mortality. Variability in metabolic parameters has recently emerged as an indicator of adverse health outcomes, including heart failure (HF).Methods We investigated whether GGT variability was associated with the incidence of hospitalisation for heart failure (HHF) in a Korean population without previous HF, ischaemic heart disease or liver disease. This longitudinal cohort study analysed 119 201 individuals from the Korean National Health Insurance Service-National Health Screening Cohort. GGT variability was calculated as the coefficient of variation (CV), SD and variability independent of the mean (VIM).Results During the 8.4 years of follow-up, 1387 cases of HHF (1.16%) developed. In the multivariable-adjusted model, the HR of HHF was 1.22 (95% CI 1.05 to 1.42) in the highest quartile of GGT variability compared with the lowest quartile, as assessed by CV after adjusting for confounding factors, including alcohol consumption and mean GGT levels. Consistent results were obtained using other indices of GGT variability such as SD (HR 1.37, 95% CI 1.16 to 1.62) and VIM (HR 1.29, 95% CI 1.11 to 1.50). In a subgroup analysis stratified by risk factor variables, although a similar relationship was observed, it was more prominent in individuals with dyslipidaemia.Conclusions The results of the present study demonstrated that variability in GGT was independently associated with the incidence of HHF. These findings suggest that higher GGT variability may be useful as an indicator of future risk of HF.