TY - JOUR T1 - Pulmonary hypertension and right ventricular involvement in hospitalised patients with COVID-19 JF - Heart JO - Heart DO - 10.1136/heartjnl-2020-317355 SP - heartjnl-2020-317355 AU - Matteo Pagnesi AU - Luca Baldetti AU - Alessandro Beneduce AU - Francesco Calvo AU - Mario Gramegna AU - Vittorio Pazzanese AU - Giacomo Ingallina AU - Antonio Napolano AU - Renato Finazzi AU - Annalisa Ruggeri AU - Silvia Ajello AU - Giulio Melisurgo AU - Paolo Guido Camici AU - Paolo Scarpellini AU - Moreno Tresoldi AU - Giovanni Landoni AU - Fabio Ciceri AU - Anna Mara Scandroglio AU - Eustachio Agricola AU - Alberto Maria Cappelletti Y1 - 2020/07/16 UR - http://heart.bmj.com/content/early/2020/07/16/heartjnl-2020-317355.abstract N2 - Objective To assess the prevalence, characteristics and prognostic value of pulmonary hypertension (PH) and right ventricular dysfunction (RVD) in hospitalised, non-intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19).Methods This single-centre, observational, cross-sectional study included 211 patients with COVID-19 admitted to non-ICU departments who underwent a single transthoracic echocardiography (TTE). Patients with poor acoustic window (n=11) were excluded. Clinical, imaging, laboratory and TTE findings were compared in patients with versus without PH (estimated systolic pulmonary artery pressure >35 mm Hg) and with versus without RVD (tricuspid annular plane systolic excursion <17 mm or S wave <9.5 cm/s). The primary endpoint was in-hospital death or ICU admission.Results A total of 200 patients were included in the final analysis (median age 62 (IQR 52–74) years, 65.5% men). The prevalence of PH and RVD was 12.0% (24/200) and 14.5% (29/200), respectively. Patients with PH were older and had a higher burden of pre-existing cardiac comorbidities and signs of more severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (radiological lung involvement, laboratory findings and oxygenation status) compared with those without PH. Conversely, patients with RVD had a higher burden of pre-existing cardiac comorbidities but no evidence of more severe SARS-CoV-2 infection compared with those without RVD. The presence of PH was associated with a higher rate of in-hospital death or ICU admission (41.7 vs 8.5%, p<0.001), while the presence of RVD was not (17.2 vs 11.7%, p=0.404).Conclusions Among hospitalised non-ICU patients with COVID-19, PH (and not RVD) was associated with signs of more severe COVID-19 and with worse in-hospital clinical outcome.Trial registration number NCT04318366 ER -