TY - JOUR T1 - Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting JF - Heart JO - Heart SP - 1495 LP - 1502 DO - 10.1136/heartjnl-2019-316118 VL - 106 IS - 19 AU - Chieh Yang Koo AU - Aye-Thandar Aung AU - Zhengfeng Chen AU - William Kristanto AU - Hui-Wen Sim AU - Wilson W Tam AU - Carlo F Gochuico AU - Kent Anthony Tan AU - Giap-Swee Kang AU - Vitaly Sorokin AU - Paul Jau Lueng Ong AU - Pipin Kojodjojo AU - Arthur Mark Richards AU - Huay-Cheem Tan AU - Theodoros Kofidis AU - Chi-Hang Lee Y1 - 2020/10/01 UR - http://heart.bmj.com/content/106/19/1495.abstract N2 - Objective Patients with advanced coronary artery disease are referred for coronary artery bypass grafting (CABG) and it remains unknown if sleep apnoea is a risk marker. We evaluated the association between sleep apnoea and major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing non-emergent CABG.Methods This was a prospective cohort study conducted between November 2013 and December 2018. Patients from four public hospitals referred to a tertiary cardiac centre for non-emergent CABG were recruited for an overnight sleep study using a wrist-worn Watch-PAT 200 device prior to CABG.Results Among the 1007 patients who completed the study, sleep apnoea (defined as apnoea-hypopnoea index ≥15 events per hour) was diagnosed in 513 patients (50.9%). Over a mean follow-up period of 2.1 years, 124 patients experienced the four-component MACCE (2-year cumulative incidence estimate, 11.3%). There was a total of 33 cardiac deaths (2.5%), 42 non-fatal myocardial infarctions (3.7%), 50 non-fatal strokes (4.9%) and 36 unplanned revascularisations (3.2%). The crude incidence of MACCE was higher in the sleep apnoea group than the non-sleep apnoea group (2-year estimate, 14.7% vs 7.8%; p=0.002). Sleep apnoea predicted the incidence of MACCE in unadjusted Cox regression analysis (HR 1.69; 95% CI 1.18 to 2.43), and remained statistically significant (adjusted HR 1.57; 95% CI 1.09 to 2.25), after adjustment for age, sex, body mass index, left ventricular ejection fraction, diabetes mellitus, hypertension, chronic kidney disease and excessive daytime sleepiness.Conclusion Sleep apnoea is independently associated with increased MACCE in patients undergoing CABG.Trial registration number NCT02701504 ER -