PT - JOURNAL ARTICLE AU - Natalie Glaser AU - Veronica Jackson AU - Per Eriksson AU - Ulrik Sartipy AU - Anders Franco-Cereceda TI - Relative survival after aortic valve surgery in patients with bicuspid aortic valves AID - 10.1136/heartjnl-2020-318733 DP - 2021 Jul 01 TA - Heart PG - 1167--1172 VI - 107 IP - 14 4099 - http://heart.bmj.com/content/107/14/1167.short 4100 - http://heart.bmj.com/content/107/14/1167.full SO - Heart2021 Jul 01; 107 AB - Objectives The objective of this cohort study was to analyse long-term relative survival in patients with bicuspid aortic valve (BAV) who underwent aortic valve surgery.Methods We studied 865 patients with BAVs who participated in three prospective cohort studies of elective, open-heart, aortic valve surgery at the Karolinska University Hospital, Stockholm, Sweden, between 2007 and 2020. The expected survival for the age, sex and calendar year-matched general Swedish population was obtained from the Human Mortality Database. The Ederer II method was used to calculate relative survival, which was used as an estimate of cause-specific survival.Results No differences were found in the observed versus expected survival at 1, 5, 10 or 12 years: 99%, 94%, 83% and 76% vs 99%, 93%, 84% and 80%, respectively. The relative survival at 1, 5, 10 and 12 years was 100% (95% CI 99% to 100%), 101% (95% CI 99% to 103%), 99% (95% CI 95% to 103%) and 95% (95% CI 87% to 102%), respectively. The relative survival at the end of follow-up tended to be lower for women than men (86% vs 95%). The mean follow-up was 6.3 years (maximum 13.3 years).Conclusions The survival of patients with BAV following aortic valve surgery was excellent and similar to that of the general population. Our results suggest that the timing of surgery according to current guidelines is correct and provide robust long-term survival rates, as well as important information about the natural history of BAV in patients following aortic valve surgery.All data relevant to the study are included in the article or uploaded as supplementary information.