TY - JOUR T1 - Clinical outcome of COVID-19 in patients with adult congenital heart disease JF - Heart JO - Heart SP - 1226 LP - 1232 DO - 10.1136/heartjnl-2020-318467 VL - 107 IS - 15 AU - Markus Schwerzmann AU - Francisco Javier Ruperti-Repilado AU - Helmut Baumgartner AU - Berto Bouma AU - Judith Bouchardy AU - Werner Budts AU - Laurence Campens AU - Massimo Chessa AU - Maria Jesús del Cerro Marin AU - Harald Gabriel AU - Pastora Gallego AU - Rocio Garcia-Orta AU - Ana Elvira Gonzalez AU - Annette Schophuus Jensen AU - Magalie Ladouceur AU - Berta Miranda-Barrio AU - Marielle Morissens AU - Agnes Pasquet AU - Joaquín Rueda AU - Annemien E van den Bosch AU - Heleen Berdina van der Zwaan AU - Daniel Tobler AU - Matthias Greutmann A2 - , Y1 - 2021/08/01 UR - http://heart.bmj.com/content/107/15/1226.abstract N2 - Aims Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD.Methods Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome.Results Of 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0).Conclusions Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.Data are available upon reasonable request. ER -