TY - JOUR T1 - Hydration for prevention of kidney injury after primary coronary intervention for acute myocardial infarction: a randomised clinical trial JF - Heart JO - Heart DO - 10.1136/heartjnl-2021-319716 SP - heartjnl-2021-319716 AU - Yong Liu AU - Ning Tan AU - Yong Huo AU - Shiqun Chen AU - Jin Liu AU - Yun-Dai Chen AU - Keng Wu AU - Guifu Wu AU - Kaihong Chen AU - Jianfeng Ye AU - Yan Liang AU - Xinwu Feng AU - Shaohong Dong AU - Qiming Wu AU - Xianhua Ye AU - Hesong Zeng AU - Minzhou Zhang AU - Min Dai AU - Chong-Yang Duan AU - Guoli Sun AU - Yibo He AU - Feier Song AU - Zhaodong Guo AU - Ping-Yan Chen AU - Junbo Ge AU - Ying Xian AU - Jiyan Chen Y1 - 2021/09/11 UR - http://heart.bmj.com/content/early/2021/09/11/heartjnl-2021-319716.abstract N2 - Objective To evaluate the efficacy of aggressive hydration compared with general hydration for contrast-induced acute kidney injury (CI-AKI) prevention among patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI).Methods The Aggressive hydraTion in patients with STEMI undergoing pPCI to prevenT Contrast-Induced Acute Kidney Injury study is an open-label, randomised controlled study at 15 teaching hospitals in China. A total of 560 adult patients were randomly assigned (1:1) to receive aggressive hydration or general hydration treatment. Aggressive hydration group received preprocedural loading dose of 125/250 mL normal saline within 30 min, followed by postprocedural hydration performed for 4 hours under left ventricular end-diastolic pressure guidance and additional hydration until 24 hours after pPCI. General hydration group received ≤500 mL 0.9% saline at 1 mL/kg/hour for 6 hours after randomisation. The primary end point is CI-AKI, defined as a >25% or 0.5 mg/dL increased in serum creatinine from baseline during the first 48–72 hours after primary angioplasty. The safety end point is acute heart failure.Results From July 2014 to May 2018, 469 patients were enrolled in the final analysis. CI-AKI occurred less frequently in aggressive hydration group than in general hydration group (21.8% vs 31.1%; risk ratio (RR) 0.70, 95% CI 0.52 to 0.96). Acute heart failure did not significantly differ between the aggressive hydration group and the general hydration group (8.1% vs 6.4%, RR 1.13, 95% CI 0.66 to 2.44). Several subgroup analysis showed the better effect of aggressive hydration in CI-AKI prevention in male, renal insufficient and non-anterior myocardial infarction participants.Conclusions Comparing with general hydration, the peri-operative aggressive hydration seems to be safe and effective in preventing CI-AKI among patients with STEMI undergoing pPCI.Data are available on reasonable request. ER -