RT Journal Article SR Electronic T1 Weight management and determinants of weight change in patients with coronary artery disease JF Heart JO Heart FD BMJ Publishing Group Ltd and British Cardiovascular Society SP 1552 OP 1559 DO 10.1136/heartjnl-2021-319224 VO 107 IS 19 A1 Tijssen, Arno A1 Snaterse, Marjolein A1 Minneboo, Madelon A1 Lachman, Sangeeta A1 Scholte op Reimer, Wilma A1 Peters, Ron J A1 Jørstad, Harald Thune YR 2021 UL http://heart.bmj.com/content/107/19/1552.abstract AB Objective To study the effects of a comprehensive secondary prevention programme on weight loss and to identify determinants of weight change in patients with coronary artery disease (CAD).Methods We performed a secondary analysis focusing on the subgroup of overweight CAD patients (BMI ≥27 kg/m2) in the Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists-2 (RESPONSE-2) multicentre randomised trial. We evaluated weight change from baseline to 12-month follow-up; multivariable logistic regression with backward elimination was used to identify determinants of weight change.Results Intervention patients (n=280) lost significantly more weight than control patients (n=257) (−2.4±7.1 kg vs −0.2±4.6 kg; p<0.001). Individual weight change varied widely, with weight gain (≥1.0 kg) occurring in 36% of interventions versus 41% controls (p=0.21). In the intervention group, weight loss of ≥5% was associated with higher age (OR 2.94), lower educational level (OR 1.91), non-smoking status (OR 2.92), motivation to start with weight loss directly after the baseline visit (OR 2.31) and weight loss programme participation (OR 3.33), whereas weight gain (≥1 kg) was associated with smoking cessation ≤6 months before or during hospitalisation (OR 3.21), non-Caucasian ethnicity (OR 2.77), smoking at baseline (OR 2.70), lower age (<65 years) (OR 1.47) and weight loss programme participation (OR 0.59).Conclusion The comprehensive secondary prevention programme was, on average, effective in achieving weight loss. However, wide variation was observed. As weight gain was observed in over one in three participants in both groups, prevention of weight gain may be as important as attempts to lose weight.Trial registration number NTR3937.Data are available on reasonable request. Requests for analyses of deidentified data from this trial should be directed to: M Snaterse (m.snaterse@hva.nl).