RT Journal Article
SR Electronic
T1 Fried-food consumption and risk of cardiovascular disease and all-cause mortality: a meta-analysis of observational studies
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1567
OP 1575
DO 10.1136/heartjnl-2020-317883
VO 107
IS 19
A1 Qin, Pei
A1 Zhang, Ming
A1 Han, Minghui
A1 Liu, Dechen
A1 Luo, Xinping
A1 Xu, Lidan
A1 Zeng, Yunhong
A1 Chen, Qing
A1 Wang, Tieqiang
A1 Chen, Xiaoliang
A1 Zhou, Qionggui
A1 Li, Quanman
A1 Qie, Ranran
A1 Wu, Xiaoyan
A1 Li, Yang
A1 Zhang, Yanyan
A1 Wu, Yuying
A1 Hu, Dongsheng
A1 Hu, Fulan
YR 2021
UL http://heart.bmj.com/content/107/19/1567.abstract
AB Objective We performed a meta-analysis, including dose–response analysis, to quantitatively determine the association of fried-food consumption and risk of cardiovascular disease and all-cause mortality in the general adult population.Methods We searched PubMed, EMBASE and Web of Science for all articles before 11 April 2020. Random-effects models were used to estimate the summary relative risks (RRs) and 95% CIs.Results In comparing the highest with lowest fried-food intake, summary RRs (95% CIs) were 1.28 (1.15 to 1.43; n=17, I2=82.0%) for major cardiovascular events (prospective: 1.24 (1.12 to 1.38), n=13, I2=75.7%; case–control: 1.91 (1.15 to 3.17), n=4, I2=92.1%); 1.22 (1.07 to 1.40; n=11, I2=77.9%) for coronary heart disease (prospective: 1.16 (1.05 to 1.29), n=8, I2=44.6%; case–control: 1.91 (1.05 to 3.47), n=3, I2=93.9%); 1.37 (0.97 to 1.94; n=4, I2=80.7%) for stroke (cohort: 1.21 (0.87 to 1.69), n=3, I2=77.3%; case–control: 2.01 (1.27 to 3.19), n=1); 1.37 (1.07 to 1.75; n=4, I2=80.0%) for heart failure; 1.02 (0.93 to 1.14; n=3, I2=27.3%) for cardiovascular mortality; and 1.03 (95% CI 0.96 to 1.12; n=6, I2=38.0%) for all-cause mortality. The association was linear for major cardiovascular events, coronary heart disease and heart failure.Conclusions Fried-food consumption may increase the risk of cardiovascular disease and presents a linear dose–response relation. However, the high heterogeneity and potential recall and misclassification biases for fried-food consumption from the original studies should be considered.Data are available upon reasonable request.