PT - JOURNAL ARTICLE AU - Tom Norris AU - Cameron Razieh AU - Francesco Zaccardi AU - Thomas Yates AU - Nazrul Islam AU - Clare L Gillies AU - Yogini V Chudasama AU - Alex V Rowlands AU - Melanie J Davies AU - Gerry P McCann AU - Amitava Banerjee AU - Carolyn S P Lam AU - Annemarie B Docherty AU - Peter JM Openshaw AU - J Kenneth Baillie AU - Malcolm Gracie Semple AU - Claire Alexandra Lawson AU - Kamlesh Khunti ED - , TI - Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19 AID - 10.1136/heartjnl-2021-320047 DP - 2021 Dec 15 TA - Heart PG - heartjnl-2021-320047 4099 - http://heart.bmj.com/content/early/2021/12/14/heartjnl-2021-320047.short 4100 - http://heart.bmj.com/content/early/2021/12/14/heartjnl-2021-320047.full AB - Objective Using a large national database of people hospitalised with COVID-19, we investigated the contribution of cardio-metabolic conditions, multi-morbidity and ethnicity on the risk of in-hospital cardiovascular complications and death.Methods A multicentre, prospective cohort study in 302 UK healthcare facilities of adults hospitalised with COVID-19 between 6 February 2020 and 16 March 2021. Logistic models were used to explore associations between baseline patient ethnicity, cardiometabolic conditions and multimorbidity (0, 1, 2, >2 conditions), and in-hospital cardiovascular complications (heart failure, arrhythmia, cardiac ischaemia, cardiac arrest, coagulation complications, stroke), renal injury and death.Results Of 65 624 patients hospitalised with COVID-19, 44 598 (68.0%) reported at least one cardiometabolic condition on admission. Cardiovascular/renal complications or death occurred in 24 609 (38.0%) patients. Baseline cardiometabolic conditions were independently associated with increased odds of in-hospital complications and this risk increased in the presence of cardiometabolic multimorbidity. For example, compared with having no cardiometabolic conditions, 1, 2 or ≥3 conditions was associated with 1.46 (95% CI 1.39 to 1.54), 2.04 (95% CI 1.93 to 2.15) and 3.10 (95% CI 2.92 to 3.29) times higher odds of any cardiovascular/renal complication, respectively. A similar pattern was observed for all-cause death. Compared with the white group, the South Asian (OR 1.19, 95% CI 1.10 to 1.29) and black (OR 1.53 to 95% CI 1.37 to 1.72) ethnic groups had higher risk of any cardiovascular/renal complication.Conclusions In hospitalised patients with COVID-19, cardiovascular complications or death impacts just under half of all patients, with the highest risk in those of South Asian or Black ethnicity and in patients with cardiometabolic multimorbidity.Data may be obtained from a third party and are not publicly available. Data and analysis scripts are available on request to the Independent Data Management and Access Committee at https://isaric4c.net/sample_access.