RT Journal Article SR Electronic T1 Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19 JF Heart JO Heart FD BMJ Publishing Group Ltd and British Cardiovascular Society SP heartjnl-2021-320047 DO 10.1136/heartjnl-2021-320047 A1 Tom Norris A1 Cameron Razieh A1 Francesco Zaccardi A1 Thomas Yates A1 Nazrul Islam A1 Clare L Gillies A1 Yogini V Chudasama A1 Alex V Rowlands A1 Melanie J Davies A1 Gerry P McCann A1 Amitava Banerjee A1 Carolyn S P Lam A1 Annemarie B Docherty A1 Peter JM Openshaw A1 J Kenneth Baillie A1 Malcolm Gracie Semple A1 Claire Alexandra Lawson A1 Kamlesh Khunti A1 , YR 2021 UL http://heart.bmj.com/content/early/2021/12/14/heartjnl-2021-320047.abstract AB Objective Using a large national database of people hospitalised with COVID-19, we investigated the contribution of cardio-metabolic conditions, multi-morbidity and ethnicity on the risk of in-hospital cardiovascular complications and death.Methods A multicentre, prospective cohort study in 302 UK healthcare facilities of adults hospitalised with COVID-19 between 6 February 2020 and 16 March 2021. Logistic models were used to explore associations between baseline patient ethnicity, cardiometabolic conditions and multimorbidity (0, 1, 2, >2 conditions), and in-hospital cardiovascular complications (heart failure, arrhythmia, cardiac ischaemia, cardiac arrest, coagulation complications, stroke), renal injury and death.Results Of 65 624 patients hospitalised with COVID-19, 44 598 (68.0%) reported at least one cardiometabolic condition on admission. Cardiovascular/renal complications or death occurred in 24 609 (38.0%) patients. Baseline cardiometabolic conditions were independently associated with increased odds of in-hospital complications and this risk increased in the presence of cardiometabolic multimorbidity. For example, compared with having no cardiometabolic conditions, 1, 2 or ≥3 conditions was associated with 1.46 (95% CI 1.39 to 1.54), 2.04 (95% CI 1.93 to 2.15) and 3.10 (95% CI 2.92 to 3.29) times higher odds of any cardiovascular/renal complication, respectively. A similar pattern was observed for all-cause death. Compared with the white group, the South Asian (OR 1.19, 95% CI 1.10 to 1.29) and black (OR 1.53 to 95% CI 1.37 to 1.72) ethnic groups had higher risk of any cardiovascular/renal complication.Conclusions In hospitalised patients with COVID-19, cardiovascular complications or death impacts just under half of all patients, with the highest risk in those of South Asian or Black ethnicity and in patients with cardiometabolic multimorbidity.Data may be obtained from a third party and are not publicly available. Data and analysis scripts are available on request to the Independent Data Management and Access Committee at https://isaric4c.net/sample_access.