RT Journal Article
SR Electronic
T1 Coronary artery disease in East and South Asians: differences observed on cardiac CT
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 251
OP 257
DO 10.1136/heartjnl-2020-318929
VO 108
IS 4
A1 Alexander Chua
A1 Daniel Adams
A1 Damini Dey
A1 Ron Blankstein
A1 Timothy Fairbairn
A1 Jonathon Leipsic
A1 Abdul Rahman Ihdayhid
A1 Brian Ko
YR 2022
UL http://heart.bmj.com/content/108/4/251.abstract
AB Epidemiological studies have observed East Asians (EAs) are significantly less likely to develop or die from coronary artery disease (CAD) compared with Caucasians. Conversely South Asians (SAs) develop CAD at higher rate and earlier age. Recently, a range of features derived from cardiac CT have been identified which may further characterise ethnic differences in CAD. Emerging data suggest EAs exhibit less coronary calcification and high-risk, non-calcified plaque compared with Caucasians on CT, with no difference in luminal stenosis. In contrast, SAs exhibit similar to higher coronary calcification and luminal stenosis, smaller luminal dimensions and more high-risk, non-calcified plaque than Caucasians. Beyond demonstrating ethnic differences in CAD, cardiac CT may enhance and individualise cardiovascular risk stratification in EAs and SAs. While data thus far in EAs have demonstrated calcium score and CT-derived luminal stenosis may incrementally predict cardiovascular risk beyond traditional risk scores, there remains a paucity of data assessing its use in SAs. Future studies may clarify the prognostic value of cardiac CT in SAs and investigate how this modality may guide preventative therapy and coronary intervention of CAD in EAs and SAs.