PT - JOURNAL ARTICLE AU - Kwak, Soongu AU - Lee, Seung-Ah AU - Lim, Jaehyun AU - Yang, Seokhun AU - Choi, Hong-Mi AU - Hwang, In-Chang AU - Lee, Sahmin AU - Yoon, Yeonyee Elizabeth AU - Park, Jun-Bean AU - Kim, Hyung-Kwan AU - Kim, Yong-Jin AU - Song, Jong-Min AU - Cho, Goo-Yeong AU - Kim, Kyung-Hwan AU - Kang, Duk-Hyun AU - Kim, Dae-Hee AU - Lee, Seung-Pyo TI - Long-term outcomes in distinct phenogroups of patients with primary mitral regurgitation undergoing valve surgery AID - 10.1136/heartjnl-2022-321305 DP - 2023 Feb 01 TA - Heart PG - 305--313 VI - 109 IP - 4 4099 - http://heart.bmj.com/content/109/4/305.short 4100 - http://heart.bmj.com/content/109/4/305.full SO - Heart2023 Feb 01; 109 AB - Objectives Patients with mitral regurgitation (MR) may be heterogeneous with different risk profiles. We aimed to identify distinct phenogroups of patients with severe primary MR and investigate their long-term prognosis after mitral valve (MV) surgery.Methods The retrospective cohort of patients with severe primary MR undergoing MV surgery (derivation, n=1629; validation, n=692) was analysed. Latent class analysis was used to classify patients into subgroups using 15 variables. The primary outcome was all-cause mortality after MV surgery.Results During follow-up (median 6.0 years), 149 patients (9.1%) died in the derivation cohort. In the univariable Cox analysis, age, female, atrial fibrillation, left ventricular (LV) end-systolic dimension/volumes, LV ejection fraction, left atrial dimension and tricuspid regurgitation peak velocity were significant predictors of mortality following MV surgery. Five distinct phenogroups were identified, three younger groups (group 1–3) and two older groups (group 4–5): group 1, least comorbidities; group 2, men with LV enlargement; group 3, predominantly women with rheumatic MR; group 4, low-risk older patients; and group 5, high-risk older patients. Cumulative survival was the lowest in group 5, followed by groups 3 and 4 (5-year survival for groups 1–5: 98.5%, 96.0%, 91.7%, 95.6% and 83.4%; p<0.001). Phenogroups had similar predictive performance compared with the Mitral Regurgitation International Database score in patients with degenerative MR (3-year C-index, 0.763 vs 0.750, p=0.602). These findings were reproduced in the validation cohort.Conclusion Five phenogroups of patients with severe primary MR with different risk profiles and outcomes were identified. This phenogrouping strategy may improve risk stratification when optimising the timing and type of interventions for severe MR.The data of this study may not be available because of ongoing projects using this data.