PT - JOURNAL ARTICLE AU - Qingmei Cui AU - Zhongying Liu AU - Jianxin Li AU - Fangchao Liu AU - Xiaoge Niu AU - Chong Shen AU - Dongsheng Hu AU - Keyong Huang AU - Shufeng Chen AU - Yingxin Zhao AU - Fanghong Lu AU - Xiaoqing Liu AU - Jie Cao AU - Laiyuan Wang AU - Hongxia Ma AU - Ling Yu AU - Xianping Wu AU - Ying Li AU - Huan Zhang AU - Xingbo Mo AU - Liancheng Zhao AU - Zhibin Hu AU - Hongbing Shen AU - Jianfeng Huang AU - Xiangfeng Lu AU - Dongfeng Gu TI - Impact of cardiovascular health and genetic risk on coronary artery disease in Chinese adults AID - 10.1136/heartjnl-2022-321657 DP - 2022 Dec 20 TA - Heart PG - heartjnl-2022-321657 4099 - http://heart.bmj.com/content/early/2023/02/02/heartjnl-2022-321657.short 4100 - http://heart.bmj.com/content/early/2023/02/02/heartjnl-2022-321657.full AB - Objective To examine whether adherence to ideal cardiovascular health (CVH) can mitigate the genetic risk of coronary artery disease (CAD) in non-European populations.Methods Fine and Grey’s models were used to calculate HRs and their corresponding 95% CIs, as well as the lifetime risk of CVH metrics across Polygenic Risk Score (PRS) categories.Results We included 39 755 individuals aged 30–75 years in Chinese prospective cohorts. 1275 CAD cases were recorded over a mean follow-up of 12.9 years. Compared with unfavourable CVH profile (zero to three ideal CVH metrics), favourable CVH profile (six to seven ideal CVH metrics) demonstrated similar relative effects across PRS categories, with the HRs of 0.40 (95% CI 0.24 to 0.67), 0.41 (95% CI 0.32 to 0.52) and 0.36 (95% CI 0.26 to 0.52) in low (bottom quintile of PRS), intermediate (two to four quintiles of PRS) and high (top quintile of PRS) PRS categories, respectively. For the absolute risk reduction (ARR), individuals with high PRS achieved the greatest benefit from favourable CVH, mitigating the risk to the average level of population (from 21.1% to 8.7%), and the gradient was strengthened in individuals at the top 5% of PRS. Moreover, compared with individuals at low PRS, those at high PRS obtained longer CAD-free years (2.6 vs 1.1) from favourable CVH at the index age of 35 years.Conclusion Favourable CVH profile reduced the CAD relative risk by similar magnitude across PRS categories, while the ARR from favourable CVH was most pronounced in high PRS category. Attaining favourable CVH should be encouraged for all individuals, especially in individuals with high genetic susceptibility.Data are available upon reasonable request.