TY - JOUR T1 - Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods. JF - British Heart Journal JO - Heart SP - 657 LP - 660 DO - 10.1136/hrt.39.6.657 VL - 39 IS - 6 AU - J S Birkhead AU - E M Vaughan Williams Y1 - 1977/06/01 UR - http://heart.bmj.com/content/39/6/657.abstract N2 - Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug. ER -