PT  - JOURNAL ARTICLE
AU  - T Sawayama
AU  - T Kurihara
AU  - S Araki
TI  - Noninvasive cardiovascular findings in familial amyloid polyneuropathy.
AID  - 10.1136/hrt.40.11.1288
DP  - 1978 Nov 01
TA  - British Heart Journal
PG  - 1288--1292
VI  - 40
IP  - 11
4099  - http://heart.bmj.com/content/40/11/1288.short
4100  - http://heart.bmj.com/content/40/11/1288.full
SO  - Heart1978 Nov 01; 40
AB  - The cardiovascular system was examined in 19 cases of familial amyloid polyneuropathy. In a group of patients with neurological involvement, various cardiac abnormalities were common, including orthostatic hypotension, prominent apex cardiographic A waves, abnormal apical systolic waves (bulges), systolic murmurs, mid-systolic clicks, QS waves, atrioventricular block, left bundlebranch block, and abnormalities of ejection time and pre-ejection period. Though there was one case with pronounced cardiac abnormality despite a normal neurological state, and though cardiovascular symptoms appeared later than neurological symptoms, the degree of cardiac involvement generally paralleled the severity of the neurological disorder.