RT Journal Article
SR Electronic
T1 Noninvasive cardiovascular findings in familial amyloid polyneuropathy.
JF British Heart Journal
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1288
OP 1292
DO 10.1136/hrt.40.11.1288
VO 40
IS 11
A1 T Sawayama
A1 T Kurihara
A1 S Araki
YR 1978
UL http://heart.bmj.com/content/40/11/1288.abstract
AB The cardiovascular system was examined in 19 cases of familial amyloid polyneuropathy. In a group of patients with neurological involvement, various cardiac abnormalities were common, including orthostatic hypotension, prominent apex cardiographic A waves, abnormal apical systolic waves (bulges), systolic murmurs, mid-systolic clicks, QS waves, atrioventricular block, left bundlebranch block, and abnormalities of ejection time and pre-ejection period. Though there was one case with pronounced cardiac abnormality despite a normal neurological state, and though cardiovascular symptoms appeared later than neurological symptoms, the degree of cardiac involvement generally paralleled the severity of the neurological disorder.